MULTICENTER FEASIBILITY STUDY OF PERCUTANEOUS RADIOFREQUENCY ABLATION OF HEPA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 具体目标： 主要目的是估计接受单独或重复经皮RFA治疗的受试者中，在治疗开始后18个月时通过CT扫描肝脏没有可识别肿瘤的受试者比例。 次要目的是： - 探索单独与重复RFA对主要目标的影响; - 探索肿瘤大小对主要目标的影响; - 评估MELD评分与主要目标之间的可能相关性; - 估计局部和远端肝内和肝外肿瘤复发率及其对主要目标的影响; - 探讨肿瘤大小对局部控制率的影响; - 探索单独或重复RFA（有或无局部/区域控制）对肝外肿瘤发展的影响; - 通过检查通过尸检或解释获得的全肝标本确定的局部肿瘤根除率与通过CT扫描确定的局部肿瘤根除率进行估计。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS: The Primary Objective is to estimate the proportion of participants undergoing solitary or repetitive percutaneous RFA treatment sessions whose livers have no identifiable tumor by CT scan at 18 months following initiation of therapy. The Secondary Objectives are to: -Explore the impact of solitary versus repetitive RFA on the primary objective; -Explore the impact of tumor size on the primary objective; -Evaluate for a possible correlation between the MELD Score and the primary objective; -Estimate the local and remote intrahepatic and extrahepatic tumor recurrence rates and their impact on the primary objective; -Explore the impact of tumor size on the local control rates; -Explore the impact of solitary or repetitive RFA with or without local/regional control the development of extra-hepatic tumor; -Estimate the local tumor eradication rate as determined by examination of whole liver specimens obtained via autopsy or explanation versus that determined by CT scan.