MULTICENTER FEASIBILITY STUDY OF PERCUTANEOUS RADIOFREQUENCY ABLATION OF HEPA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 具体目标： 主要目标是估计在开始治疗18个月后，接受单独或重复的经皮RFA治疗的参与者的肝脏在CT扫描中未发现肿瘤的比例。 次要目标是： -探讨单独或重复射频消融对主要目标的影响； -探索肿瘤大小对主要目标的影响； -评估MELD评分与主要目标之间可能存在的关联； -估计局部和远程肝内和肝外肿瘤复发率及其对主要目标的影响； -探讨肿瘤大小对局部控制率的影响； -探讨单独或重复射频治疗对肝外肿瘤发展的影响； -估计通过尸检或解释获得的全肝样本与通过CT扫描确定的局部肿瘤清除率。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS: The Primary Objective is to estimate the proportion of participants undergoing solitary or repetitive percutaneous RFA treatment sessions whose livers have no identifiable tumor by CT scan at 18 months following initiation of therapy. The Secondary Objectives are to: -Explore the impact of solitary versus repetitive RFA on the primary objective; -Explore the impact of tumor size on the primary objective; -Evaluate for a possible correlation between the MELD Score and the primary objective; -Estimate the local and remote intrahepatic and extrahepatic tumor recurrence rates and their impact on the primary objective; -Explore the impact of tumor size on the local control rates; -Explore the impact of solitary or repetitive RFA with or without local/regional control the development of extra-hepatic tumor; -Estimate the local tumor eradication rate as determined by examination of whole liver specimens obtained via autopsy or explanation versus that determined by CT scan.