GENETICS OF CV DISEASE AND COGNIITIVE IMPAIRMENT IN THE DIABETES HEART STUDY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在老年人群中，很大比例的痴呆病例不是由阿尔茨海默病(AD)引起的，而是由脑血管疾病引起的。脑血管疾病引起的痴呆，广泛地描述为中风，被称为血管性痴呆或血管认知障碍(VCI)。尽管VCI的患病率很高，但对这种疾病的生物学基础的研究比AD要少得多。VCI的一个显著特点是，仅凭医学诊断很难预测。这表明未知的遗传因素可能在一个人患VCI的易感性中起作用。这项研究旨在通过磁共振成像(MRI)和认知能力(通过一系列智力功能测试)准确地测量2型糖尿病家庭人口中的脑血管疾病，糖尿病心脏研究(DHS)。国土安全部从450个家庭招募了1200多名受试者，并对动脉粥样硬化、身体成分、骨密度和其他临床指标进行了广泛而复杂的测量。此外，作为国土安全部的一部分，正在进行全基因组扫描，这将为每个个体的每个染色体的每个部分创建一个遗传标记数据库。家属将接受核磁共振扫描和认知测试。首先，我们将估计遗传学对国土安全部家庭中脑血管疾病和认知障碍的影响程度(即遗传率的估计)。其次，核磁共振扫描和认知测试的结果将被用来定位影响这些特征的基因。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A large proportion of dementia cases in the aged population are not due to Alzheimers disease (AD), but rather to cerebrovascular disease. Dementia due to cerebrovascular disease, broadly described as stroke, is referred to as vascular dementia or vascular cognitive impairment (VCI). Despite the enormous prevalence of VCI, the biological basis of this disease has been much less well studied than AD. A striking feature of VCI is that it is difficult to predict based on medical diagnosis alone. This suggests that unknown genetic factors may play a role in a person's susceptibily to develop VCI. This study is designed to accurately measure cerebrovascular disease through magnetic resonance imaging (MRI) and cognitive ability(through a battery of tests for intellectual functioning) in a population of families highly enriched for the presence of type 2 diabetes, the Diabetes Heart Study (DHS). The DHS has recruited over 1200 subjects from 450 families and has extensive sophisticated measures of atherosclerosis, body composition, bone density, and other clinical measures. In addition, as part of the DHS, a genome-wide scan is being performed which will create a database of inheritance markers for each part of each chromosome in each individual. Family members will be given MRI scans and cognitive tests. Initially we will estimate the extent that genetics contributes to cerebrovascular disease and cognitive impairment (i.e. estimates of heritability) in the DHS families. Second, results from the MRI scans and cognitive tests will be used to map genes that influence these traits.