Wake Forest APOLLO Scientific and Data Research Center
维克森林阿波罗科学与数据研究中心
基本信息
- 批准号:9440610
- 负责人:
- 金额:$ 75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-25 至 2022-05-31
- 项目状态:已结题
- 来源:
- 关键词:APOL1 geneAcuteAdultAfricanAfrican AmericanAllograftingAmericanAncillary StudyAntibodiesApolipoproteinsArchivesAreaBiometryCharacteristicsChildhoodClinicalClinical DataCohort StudiesCollectionCommunicationCountryCreatinineDNADataData AnalysesData QualityData SecurityDevelopmentEnd stage renal failureEnsureEthicistsEthicsEthnic groupEuropeanEvaluationFailureFundingGenesGeneticGenotypeGlomerular Filtration RateHealthHealth Care CostsHistologicHuman ResourcesInformed ConsentKidneyKidney TransplantationLaboratoriesLeadLeadershipLinkLiving DonorsManualsMonitorMulticenter StudiesNational Institute of Diabetes and Digestive and Kidney DiseasesNephrologyOnline SystemsOperative Surgical ProceduresOrganOrgan ProcurementsOutcomePatientsPhysiciansPopulationPredispositionPreparationProceduresProcessProspective StudiesProteinuriaProtocols documentationQuality of lifeRaceRenal functionReportingRequest for ApplicationsResearchResearch PersonnelResourcesRetrospective StudiesRiskRisk EstimateSafetySamplingSerumSickle HemoglobinSpecimenStatistical Data InterpretationStructureSystemTimeTransplant RecipientsTransplantationUnited Network for Organ SharingUnited States National Institutes of HealthVariantVirus DiseasesVital Statusbasebiobankdesignethnic disparityforestgenetic informationimprovedimproved outcomeindexingkidney allograftnon-diabeticorgan allocationprecision medicineprimary outcomeprogramsprospectiveracial and ethnicracial disparityrepositoryresponserisk variantscreeningskillstoolweb site
项目摘要
The NIH APOL1 Long-term Transplantation Outcomes Network (APOLLO) Collaborative U01 will perform a
national prospective evaluation of donor and recipient APOL1 renal-risk variants in all US kidney transplants
from African American kidney donors to determine their effect on transplant outcomes. In addition, the post-
donation health and kidney function of African American living kidney donors will be assessed. We are
applying to be the APOLLO Scientific and Data Research Center (SDRC) for this NIH Funding Announcement.
Shorter renal allograft survival is observed for transplantations from deceased African American kidney donors,
relative to deceased European American kidney donors. Reasons for this are unknown, but retrospective
reports suggest that presence of two apolipoprotein L1 gene (APOL1) renal-risk variants in kidney donors may
contribute to the disparity. These variants are common in populations with recent African ancestry (such as
African Americans), where they are strongly associated with non-diabetic end-stage kidney disease, but rare in
other racial/ethnic groups. APOL1 genotype data may provide more accurate assessment of the likelihood for
long-term renal allograft function in donor kidneys, thereby improving the matching of donor kidneys with
potential recipients in order to optimize renal allograft and patient survival. This information may better inform
physicians about organ quality prior to decisions on allocation are made and regarding the safety of living
kidney donation. Before this genotypic data can be used clinically, a prospective national study is required to
evaluate all kidney transplantation outcomes from African American donors and recipients of their kidneys
based on APOL1 genotypes. Information lacking from retrospective studies needs to be collected, including
recipient APOL1 genotypes, renal histologic data in failed allografts and presence or development of BK viral
infections, donor specific antibodies, and acute rejections after kidney transplantation. We will perform the
following activities for the APOLLO Network: overall study coordination, assist with preparation of the final
protocol and Manual of Procedures, develop data tracking tools and the study website, collect and archive
clinical and outcomes data, perform genotyping, statistical analyses, assessment of the primary outcome “time
to allograft failure in transplanted kidneys from African American donors, based on donor APOL1 genotypes”
and create a bio-repository. We will longitudinally assess vital status, kidney function and proteinuria in living
African American kidney donors based on APOL1 genotypes. Prospective assessment of the effects of kidney
donor APOL1 genotypes on serum creatinine concentration, estimated glomerular filtration rate, and
proteinuria in transplant recipients with functioning allografts will also be performed. Results have the potential
to transform the organ allocation and informed consent processes in kidney transplantation, optimize renal
allograft survival, reduce the discard of good-quality kidneys, and protect the health of living kidney donors.
NIH APOL1长期移植结果网络(APOLLO)合作U01将执行一项研究
项目成果
期刊论文数量(0)
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DONALD W BOWDEN其他文献
DONALD W BOWDEN的其他文献
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{{ truncateString('DONALD W BOWDEN', 18)}}的其他基金
Wake Forest APOLLO Scientific and Data Research Center
维克森林阿波罗科学与数据研究中心
- 批准号:
9975002 - 财政年份:2017
- 资助金额:
$ 75万 - 项目类别:
Wake Forest APOLLO Scientific and Data Research Center
维克森林阿波罗科学与数据研究中心
- 批准号:
10215268 - 财政年份:2017
- 资助金额:
$ 75万 - 项目类别:
14/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Scientific Data Research Center
14/14 APOL1长期肾移植结果网络(APOLLO)科学数据研究中心
- 批准号:
10728589 - 财政年份:2017
- 资助金额:
$ 75万 - 项目类别:
Wake Forest APOLLO Scientific and Data Research Center
维克森林阿波罗科学与数据研究中心
- 批准号:
10475327 - 财政年份:2017
- 资助金额:
$ 75万 - 项目类别:
Wake Forest APOLLO Scientific and Data Research Center
维克森林阿波罗科学与数据研究中心
- 批准号:
10490832 - 财政年份:2017
- 资助金额:
$ 75万 - 项目类别:
Metabolomic Signatures of CAD Associated Genotypes
CAD 相关基因型的代谢组学特征
- 批准号:
9172683 - 财政年份:2016
- 资助金额:
$ 75万 - 项目类别:
Metabolomic Signatures of CAD Associated Genotypes
CAD 相关基因型的代谢组学特征
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9334928 - 财政年份:2016
- 资助金额:
$ 75万 - 项目类别:
Exome Sequencing to Identify CVD Risk Variants in Hispanics & African Americans
外显子组测序识别西班牙裔 CVD 风险变异
- 批准号:
8464763 - 财政年份:2012
- 资助金额:
$ 75万 - 项目类别:
Exome Sequencing to Identify CVD Risk Variants in Hispanics & African Americans
外显子组测序识别西班牙裔 CVD 风险变异
- 批准号:
8507934 - 财政年份:2012
- 资助金额:
$ 75万 - 项目类别:
Exome Sequencing to Identify CVD Risk Variants in Hispanics & African Americans
外显子组测序识别西班牙裔 CVD 风险变异
- 批准号:
8660319 - 财政年份:2012
- 资助金额:
$ 75万 - 项目类别:
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