14/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Scientific Data Research Center
14/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Scientific Data Research Center
批准号:
10728589
负责人:
DONALD W BOWDEN
金额:
$90.1万
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
未结题
起止时间:
2017-09-25 至 2028-05-31
关键词:
APOL1 geneAcuteAdultAfrican AmericanAfrican American populationAfrican ancestryAllograftingAmericanAncillary StudyApolipoproteinsArchivesBioinformaticsBiometryChildhoodChronic Kidney FailureClinicalClinical DataCohort StudiesCollectionCommunitiesCreatinineDNADataData AnalysesDatabasesDecision MakingDevelopmentDisparityEligibility DeterminationEngraftmentEnrollmentEnsureEthicistsEthicsEthnic PopulationEuropeanEvaluationFailureGenesGeneticGenotypeGlomerular Filtration RateGraft SurvivalHealthHealth Care CostsHealth protectionHistologyHuman ResourcesIndividualInformed ConsentInstitutional Review BoardsKidneyKidney TransplantationLaboratoriesLeadershipLinkManualsMonitorMulticenter StudiesNational Institute of Diabetes and Digestive and Kidney DiseasesNephrologyObservational StudyOperative Surgical ProceduresOrganOrgan ProcurementsOutcomeOutcome AssessmentParticipantPatientsPhysiciansPopulationPredispositionProceduresProcessProspective StudiesProteinuriaProtocols documentationPublicationsQuality of lifeRenal functionReportingResearchResearch PersonnelResourcesRetrospective StudiesRiskSafetySamplingSerumSickle HemoglobinStatistical Data InterpretationStructureTimeTransplant RecipientsTransplantationUnited Network for Organ SharingUnited States National Institutes of HealthUniversitiesVariantVirus DiseasesVital StatusWorkbiobankclinical centerdata qualitydesigndonor-specific antibodyethnic disparityforestgenetic informationgenome-widegraft functionimprovedkidney allograftliving kidney donormedical schoolsorgan allocationorgan procurement transplantation networkpost-transplantprecision medicineprimary outcomeprogramsprospectiveracial populationrecruitrepositoryresponserisk variantskillstoolweb siteworking group
中文摘要
美国国立卫生研究院APOL1长期移植结果网络(APOLLO)合作U01正在进行一项研究
英文摘要
The NIH APOL1 Long-term Transplantation Outcomes Network (APOLLO) Collaborative U01 is performing a
national prospective evaluation of donor and recipient apolipoprotein L1 gene (APOL1) risk variants in US kidney
transplants from African American donors to determine their effect on transplant outcomes. In addition, post-
donation health and kidney function of African American living kidney donors will be assessed. We are applying
to continue serving as the APOLLO Scientific and Data Research Center (SDRC). Shorter renal allograft survival
is observed for transplantations from deceased African American kidney donors, relative to deceased European
American kidney donors. Reasons for this are unknown, but retrospective reports suggest that presence of two
APOL1 risk variants in kidney donors may contribute to the disparity. These variants are common in populations
with recent African ancestry (such as African Americans), where they are strongly associated with chronic kidney
disease, but rare in other racial/ethnic groups. APOL1 genotype data may provide more accurate assessment
of the likelihood for long-term renal allograft function in donor kidneys, thereby improving matching of donor
kidneys with potential recipients in order to optimize renal allograft and patient survival. This information may
better inform physicians about organ quality prior to making decisions on allocation. It may also inform the safety
of living kidney donation. Before APOL1 genotypes can be used clinically, the prospective national APOLLO
study was required to evaluate kidney transplant outcomes from African American donors and recipients of their
kidneys based on APOL1. APOLLO collects information lacking from retrospective studies, including recipient
APOL1 genotypes, renal histology in engrafted kidneys and presence or development of BK viral infections,
donor specific antibodies, and acute rejections after kidney transplantation. We apply to continue to perform
these activities for the APOLLO Network: overall study coordination, assist with ensuring compliance with the
Protocol and Manual of Procedures, maintain data tracking tools and the study website, collect and archive
clinical and outcomes data, perform genotyping, statistical analyses, assessment of outcomes including the
primary outcome “time to allograft failure in transplanted kidneys from African American donors based on donor
APOL1 genotypes”, and complete the bio-repository. We will longitudinally assess vital status, kidney function
and proteinuria in living African American kidney donors based on APOL1 genotypes and prospectively assess
effects of donor APOL1 genotypes on serum creatinine concentration, estimated glomerular filtration rate, and
proteinuria in kidney transplant recipients with functioning grafts. APOLLO results have the potential to transform
the organ allocation and informed consent processes in kidney transplantation, optimize renal allograft survival,
reduce discard of good-quality kidneys, and protect the health of living kidney donors.
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DOI:
10.1016/j.kint.2020.11.025
发表时间:
2021-07
期刊:
Kidney international
影响因子:
19.6
作者:
[Freedman BI, Poggio ED]
通讯作者:
Poggio ED
Recipient APOL1 Genotype Effects on Outcomes After Kidney Transplantation.
受者 APOL1 基因型对肾移植后结果的影响。
DOI:
10.1053/j.ajkd.2021.11.001
发表时间:
2022
期刊:
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子:
--
作者:
[Freedman,BarryI, Mena-Gutierrez,AlejandraM, Ma,Lijun]
通讯作者:
Ma,Lijun
DOI:
10.1097/tp.0000000000002509
发表时间:
2019-03
期刊:
Transplantation
影响因子:
6.2
作者:
[Ma L, Divers J, Freedman BI]
通讯作者:
Freedman BI
DOI:
10.1097/tp.0000000000003641
发表时间:
2021-10-01
期刊:
Transplantation
影响因子:
6.2
作者:
[Doshi MD, Gordon EJ, Freedman BI, Glover C, Locke JE, Thomas CP]
通讯作者:
Thomas CP
DOI:
10.1111/ctr.14516
发表时间:
2022-01
期刊:
Clinical transplantation
影响因子:
2.1
作者:
[]
通讯作者:
Wake Forest APOLLO Scientific and Data Research Center
-
批准号:9975002
-
项目类别:
-
资助金额:$5.0万
-
财政年份:2017
-
负责人:DONALD W BOWDEN
-
依托单位:
Wake Forest APOLLO Scientific and Data Research Center
-
批准号:10215268
-
项目类别:
-
资助金额:$75.0万
-
财政年份:2017
-
负责人:DONALD W BOWDEN
-
依托单位:
Wake Forest APOLLO Scientific and Data Research Center
-
批准号:9440610
-
项目类别:
-
资助金额:$75.0万
-
财政年份:2017
-
负责人:DONALD W BOWDEN
-
依托单位:
Wake Forest APOLLO Scientific and Data Research Center
-
批准号:10475327
-
项目类别:
-
资助金额:$20.93万
-
财政年份:2017
-
负责人:DONALD W BOWDEN
-
依托单位:
Wake Forest APOLLO Scientific and Data Research Center
-
批准号:10490832
-
项目类别:
-
资助金额:$75.0万
-
财政年份:2017
-
负责人:DONALD W BOWDEN
-
依托单位:
Metabolomic Signatures of CAD Associated Genotypes
-
批准号:9172683
-
项目类别:
-
资助金额:$68.75万
-
财政年份:2016
-
负责人:DONALD W BOWDEN
-
依托单位:
Metabolomic Signatures of CAD Associated Genotypes
-
批准号:9334928
-
项目类别:
-
资助金额:$62.25万
-
财政年份:2016
-
负责人:DONALD W BOWDEN
-
依托单位:
Exome Sequencing to Identify CVD Risk Variants in Hispanics & African Americans
-
批准号:8464763
-
项目类别:
-
资助金额:$111.45万
-
财政年份:2012
-
负责人:DONALD W BOWDEN
-
依托单位:
Exome Sequencing to Identify CVD Risk Variants in Hispanics & African Americans
-
批准号:8507934
-
项目类别:
-
资助金额:$3.54万
-
财政年份:2012
-
负责人:DONALD W BOWDEN
-
依托单位:
Exome Sequencing to Identify CVD Risk Variants in Hispanics & African Americans
-
批准号:8660319
-
项目类别:
-
资助金额:$116.18万
-
财政年份:2012
-
负责人:DONALD W BOWDEN
-
依托单位:
Exome Sequencing to Identify CVD Risk Variants in Hispanics & African Americans
-
批准号:8279813
-
项目类别:
-
资助金额:$51.75万
-
财政年份:2012
-
负责人:DONALD W BOWDEN
-
依托单位:
Exome Sequencing to Identify CVD Risk Variants in Hispanics & African Americans
-
批准号:8969790
-
项目类别:
-
资助金额:$8.87万
-
财政年份:2012
-
负责人:DONALD W BOWDEN
-
依托单位:
Exome Sequencing to Identify CVD Risk Variants in Hispanics & African Americans
-
批准号:8819141
-
项目类别:
-
资助金额:$103.26万
-
财政年份:2012
-
负责人:DONALD W BOWDEN
-
依托单位:
GENETICS OF CV DISEASE AND COGNIITIVE IMPAIRMENT IN THE DIABETES HEART STUDY
-
批准号:8167010
-
项目类别:
-
资助金额:$13.39万
-
财政年份:2010
-
负责人:DONALD W BOWDEN
-
依托单位:
Whole Genome Association Analysis of the Diabetes Heart Study
-
批准号:8054931
-
项目类别:
-
资助金额:$71.7万
-
财政年份:2010
-
负责人:DONALD W BOWDEN
-
依托单位:
Whole Genome Association Analysis of the Diabetes Heart Study
-
批准号:8441612
-
项目类别:
-
资助金额:$63.02万
-
财政年份:2010
-
负责人:DONALD W BOWDEN
-
依托单位:
Whole Genome Association Analysis of the Diabetes Heart Study
-
批准号:7782636
-
项目类别:
-
资助金额:$72.43万
-
财政年份:2010
-
负责人:DONALD W BOWDEN
-
依托单位:
Whole Genome Association Analysis of the Diabetes Heart Study
-
批准号:8233558
-
项目类别:
-
资助金额:$63.54万
-
财政年份:2010
-
负责人:DONALD W BOWDEN
-
依托单位:
GENETICS OF CV DISEASE AND COGNIITIVE IMPAIRMENT IN THE DIABETES HEART STUDY
-
批准号:7951377
-
项目类别:
-
资助金额:$3.99万
-
财政年份:2009
-
负责人:DONALD W BOWDEN
-
依托单位:
Genetic Epidemiology of Cerebrovascular Disease and Cognition in Diabetes
-
批准号:7869523
-
项目类别:
-
资助金额:$23.84万
-
财政年份:2008
-
负责人:DONALD W BOWDEN
-
依托单位:
海外基金