权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

14/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Scientific Data Research Center

14/14 APOL1长期肾移植结果网络（APOLLO）科学数据研究中心

基本信息

批准号：
10728589
负责人：
DONALD W BOWDEN
金额：
$ 90.1万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-25 至 2028-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10728589
关键词：
APOL1 gene Acute Adult African American African American population African ancestry Allografting American Ancillary Study Apolipoproteins Archives Bioinformatics Biometry Childhood Chronic Kidney Failure Clinical Clinical Data Cohort Studies Collection Communities Creatinine DNA Data Data Analyses Databases Decision Making Development Disparity Eligibility Determination Engraftment Enrollment Ensure Ethicists Ethics Ethnic Population European Evaluation Failure Genes Genetic Genotype Glomerular Filtration Rate Graft Survival Health Health Care Costs Health protection Histology Human Resources Individual Informed Consent Institutional Review Boards Kidney Kidney Transplantation Laboratories Leadership Link Manuals Monitor Multicenter Studies National Institute of Diabetes and Digestive and Kidney Diseases Nephrology Observational Study Operative Surgical Procedures Organ Organ Procurements Outcome Outcome Assessment Participant Patients Physicians Population Predisposition Procedures Process Prospective Studies Proteinuria Protocols documentation Publications Quality of life Renal function Reporting Research Research Personnel Resources Retrospective Studies Risk Safety Sampling Serum Sickle Hemoglobin Statistical Data Interpretation Structure Time Transplant Recipients Transplantation United Network for Organ Sharing United States National Institutes of Health Universities Variant Virus Diseases Vital Status Work biobank clinical center data quality design donor-specific antibody ethnic disparity forest genetic information genome-wide graft function improved kidney allograft living kidney donor medical schools organ allocation organ procurement transplantation network post-transplant precision medicine primary outcome programs prospective racial population recruit repository response risk variant skills tool web site working group

项目摘要

The NIH APOL1 Long-term Transplantation Outcomes Network (APOLLO) Collaborative U01 is performing a national prospective evaluation of donor and recipient apolipoprotein L1 gene (APOL1) risk variants in US kidney transplants from African American donors to determine their effect on transplant outcomes. In addition, post- donation health and kidney function of African American living kidney donors will be assessed. We are applying to continue serving as the APOLLO Scientific and Data Research Center (SDRC). Shorter renal allograft survival is observed for transplantations from deceased African American kidney donors, relative to deceased European American kidney donors. Reasons for this are unknown, but retrospective reports suggest that presence of two APOL1 risk variants in kidney donors may contribute to the disparity. These variants are common in populations with recent African ancestry (such as African Americans), where they are strongly associated with chronic kidney disease, but rare in other racial/ethnic groups. APOL1 genotype data may provide more accurate assessment of the likelihood for long-term renal allograft function in donor kidneys, thereby improving matching of donor kidneys with potential recipients in order to optimize renal allograft and patient survival. This information may better inform physicians about organ quality prior to making decisions on allocation. It may also inform the safety of living kidney donation. Before APOL1 genotypes can be used clinically, the prospective national APOLLO study was required to evaluate kidney transplant outcomes from African American donors and recipients of their kidneys based on APOL1. APOLLO collects information lacking from retrospective studies, including recipient APOL1 genotypes, renal histology in engrafted kidneys and presence or development of BK viral infections, donor specific antibodies, and acute rejections after kidney transplantation. We apply to continue to perform these activities for the APOLLO Network: overall study coordination, assist with ensuring compliance with the Protocol and Manual of Procedures, maintain data tracking tools and the study website, collect and archive clinical and outcomes data, perform genotyping, statistical analyses, assessment of outcomes including the primary outcome “time to allograft failure in transplanted kidneys from African American donors based on donor APOL1 genotypes”, and complete the bio-repository. We will longitudinally assess vital status, kidney function and proteinuria in living African American kidney donors based on APOL1 genotypes and prospectively assess effects of donor APOL1 genotypes on serum creatinine concentration, estimated glomerular filtration rate, and proteinuria in kidney transplant recipients with functioning grafts. APOLLO results have the potential to transform the organ allocation and informed consent processes in kidney transplantation, optimize renal allograft survival, reduce discard of good-quality kidneys, and protect the health of living kidney donors.

美国国立卫生研究院APOL1长期移植结果网络（APOLLO）合作U01正在进行一项研究

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

APOL1 genotyping in kidney transplantation: to do or not to do, that is the question? (pro).

DOI：
10.1016/j.kint.2020.11.025
发表时间：
2021-07
期刊：
Kidney international
影响因子：
19.6
作者：
Freedman BI;Poggio ED
通讯作者：
Poggio ED

Recipient APOL1 Genotype Effects on Outcomes After Kidney Transplantation.

受者 APOL1 基因型对肾移植后结果的影响。

DOI：
10.1053/j.ajkd.2021.11.001
发表时间：
2022
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
0
作者：
Freedman,BarryI;Mena-Gutierrez,AlejandraM;Ma,Lijun
通讯作者：
Ma,Lijun

Mechanisms of Injury in APOL1-associated Kidney Disease.