EXCERCISE LIPID BW

运动脂质 BW

• 批准号: 7951439
• 负责人: Teletia Renee Taylor
• 金额: $ 20.11万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951439
• 关键词: Aerobic Exercise; Affect; African; African American; Age; Cancer Cell Growth; Caucasians; Caucasoid Race; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Control Groups; Data Collection; Diet; Exercise; Fatty acid glycerol esters; Funding; Grant; IGF1 gene; Incidence; Institution; Insulin; Insulin-Like Growth Factor I; Intervention; Life Style; Lipids; Malignant neoplasm of prostate; PSA level; Prostate-Specific Antigen; Randomized; Recruitment Activity; Research; Research Personnel; Resources; Risk; SHBG gene; Serum; Sex Hormone-Binding Globulin; Source; Testosterone; United States National Institutes of Health; Universities; human IGFBP2 protein; men; sedentary

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: African-American men have the highest incidence of prostate cancer in the world. The incidence of prostate cancer in African-American men is 59% greater than in Caucasian men. The exact cause for the increased incidence of prostate cancer in African-American is unknown. However, a diet high in fat and/or a sedentary lifestyle may predispose African-African men to prostate cancer by affecting levels of serum factors that potentate the growth of the cancer cells such as free testosterone, sex hormone-binding globulin (SHBG), insulin, insulin-like growth factor-1 (IGF1), prostate-specific antigen (PSA), and insulin-like growth factor binding proteins- 2 and 3. Aims and Objectives: 1. To recruit 40 African-American men between the ages of 40 and 70 who are at increased risk for developing prostate cancer and randomize them into an exercise intervention or control group. 2. To examine the effect of 12 days of aerobic exercise over 4 weeks on PSA levels in African-American men who have PSA levels under 4.0 ng/ml. 3. To examine the effect of 12 days of aerobic exercise on free and total testosterone, insulin, IGF1, and SHBG levels in African-American men. Progress to date: Data collection still in progress. Continuation of grant has been requested.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 背景资料： 非裔美国人是世界上前列腺癌发病率最高的人群。 非裔美国男性的前列腺癌发病率比白人男性高59%。 非裔美国人前列腺癌发病率增加的确切原因尚不清楚。 然而，高脂肪饮食和/或久坐不动的生活方式可能通过影响血清因子水平而使非洲裔男性易患前列腺癌，这些血清因子可增强癌细胞的生长，如游离睾酮、性激素结合球蛋白SHBG、胰岛素、胰岛素样生长因子-1 IGF 1、前列腺特异性抗原PSA和胰岛素样生长因子结合蛋白-2和3。 宗旨和目标： 1. 招募40名年龄在40至70岁之间的非裔美国男性，他们患前列腺癌的风险增加，并将他们随机分为运动干预组或对照组。 2.在PSA水平低于4.0 ng/ml的非裔美国男性中，研究为期4周的12天有氧运动对PSA水平的影响。 3. 研究12天有氧运动对非裔美国男性游离和总睾酮、胰岛素、IGF 1和SHBG水平的影响。 迄今取得的进展：数据收集仍在进行中。已申请继续资助。