CARDIOVASCULAR MRI IN CHILDHOOD CANCER SURVIVORS (PILOT STUDY)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 接受治疗的儿童恶性肿瘤的长期幸存者经历了心血管事件的发生率增加，包括急性冠状动脉和脑血管综合征，以及充血性心力衰竭(CHF)。癌症治疗(化疗和放射治疗)的这些令人不快的长期并发症对20至40岁相对健康的人的功能能力、发病率和死亡率产生了不利影响。目前，尚不存在识别发生心血管事件风险增加的无症状癌症幸存者的标志物。此外，对癌症治疗可能影响心血管事件发生的机制的了解尚不清楚。 MRI标记物在老年人中是精确的，可以独立于高血压、糖尿病和高胆固醇血症等临床条件的存在来预测心血管事件，这些因素也被认为与不良结果有关。因此，我们建议将心脏磁共振应用于儿童癌症幸存者心血管健康的机构先导性研究。我们的首要目标是评估CMRI在描述处于危险中的儿童癌症幸存者的不良心血管结局预测因素中的作用。为了完成这些提交，我们需要确定获取儿童癌症幸存者的预后MRI信息的可行性，并确定这些MRI测量在年轻成人人群中的差异，以便在未来的研究中确定样本量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Long term survivors of treated childhood malignancies experience an increased incidence of cardiovascular events including acute coronary and cerebro-vascular syndromes, and congestive heart failure (CHF). These untoward, long-term complications of cancer treatment (chemotherapy and radiation therapy) adversely impact the functional capacity, morbidity, and mortality of otherwise relatively healthy 20 to 40 year-old individuals. At present, markers to identify asymptomatic cancer survivors at increased risk of developing cardiovascular events do not exist. Moreover, understanding of the mechanisms by which cancer treatment could influence the occurrence of cardiovascular events is unavailable. MRI markers are precise in older adults, and forecast cardiovascular events independent of the presence of clinical conditions, such as hypertension, diabetes, and hypercholesterolemia that are also known to be associated with adverse outcomes. We therefore propose to apply cardiac MRI in an institutional pilot study of cardiovascular health in childhood cancer survivors. Our overarching goal is to evaluate the utility of cMRI in delineating predictors of adverse cardiovascular outcomes in childhood cancer survivors at risk. To accomplish these submissions, we need to determine the feasibility of acquiring prognostic MRI information in survivors of childhood cancer, and define the variance of these MRI measures in a young adult population for determining sample sizes in future studies.