CARDIOVASCULAR MRI IN CHILDHOOD CANCER SURVIVORS PILOT STUDY

儿童癌症幸存者的心血管 MRI 试点研究

• 批准号: 8167034
• 负责人: SHARON MARIE CASTELLINO
• 金额: $ 0.52万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167034
• 关键词: Activities of Daily Living; Acute; Blood Vessels; Cancer Survivor; Cardiac; Cardiovascular system; Childhood; Clinical; Computer Retrieval of Information on Scientific Projects Database; Congestive Heart Failure; Coronary; Diabetes Mellitus; Elderly; Event; Funding; Future; Goals; Grant; Health; Hypertension; Incidence; Individual; Institution; Long-Term Survivors; Magnetic Resonance Imaging; Malignant Neoplasms; Measures; Morbidity - disease rate; Outcome; Pilot Projects; Population; Radiation therapy; Research; Research Personnel; Resources; Risk; Sample Size; Source; Syndrome; United States National Institutes of Health; adverse outcome; cancer therapy; chemotherapy; childhood cancer survivor; experience; hypercholesterolemia; mortality; prognostic; young adult

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Long term survivors of treated childhood malignancies experience an increased incidence of cardiovascular events including acute coronary and cerebro-vascular syndromes, and congestive heart failure (CHF). These untoward, long-term complications of cancer treatment (chemotherapy and radiation therapy) adversely impact the functional capacity, morbidity, and mortality of otherwise relatively healthy 20 to 40 year-old individuals. At present, markers to identify asymptomatic cancer survivors at increased risk of developing cardiovascular events do not exist. Moreover, understanding of the mechanisms by which cancer treatment could influence the occurrence of cardiovascular events is unavailable. MRI markers are precise in older adults, and forecast cardiovascular events independent of the presence of clinical conditions, such as hypertension, diabetes, and hypercholesterolemia that are also known to be associated with adverse outcomes. We therefore propose to apply cardiac MRI in an institutional pilot study of cardiovascular health in childhood cancer survivors. Our overarching goal is to evaluate the utility of cMRI in delineating predictors of adverse cardiovascular outcomes in childhood cancer survivors at risk. To accomplish these submissions, we need to determine the feasibility of acquiring prognostic MRI information in survivors of childhood cancer, and define the variance of these MRI measures in a young adult population for determining sample sizes in future studies.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 治疗的儿童恶性肿瘤的长期幸存者经历了心血管事件的发病率增加，包括急性冠状动脉和脑血管综合征，以及充血性心力衰竭（CHF）。癌症治疗（化学疗法和放射疗法）的这些不良，长期的并发症会对其他相对健康的20至40岁患者的功能能力，发病率和死亡率产生不利影响。目前，尚不存在识别出无症状的癌症幸存者患心血管事件风险增加的标记。此外，了解癌症治疗可能影响心血管事件发生的机制是不可用的。 在老年人中，MRI标记是精确的，并且预测心血管事件与临床状况的存在，例如高血压，糖尿病和高胆固醇血症，这也已知与不良后果有关。因此，我们建议在儿童癌症幸存者的心血管健康的机构试点研究中应用心脏MRI。我们的总体目标是评估CMRI在划定危险中儿童癌症幸存者不良心血管结局预测指标中的效用。为了完成这些提交，我们需要确定在儿童癌症幸存者中获取预后的MRI信息的可行性，并确定年轻成人人群中这些MRI测量的差异，以确定未来研究中的样本量。