INSPIRATORY AIRFLOW DYNAMICS, METABOLIC SYNDROME, AND HYPERAROUSAL IN PATIENTS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 在这项研究中，我们建议比较治疗性鼻CPAP与安慰剂鼻CPAP对上气道阻力综合征（UARS）患者功能性主诉的影响（即，疲劳、白天嗜睡、睡眠问题、胃肠道过敏、头痛、焦虑和身体疼痛）。 本研究的一个目的是收集试点数据，检查防止上呼吸道塌陷在睡眠期间对UARS患者的代谢功能的影响。 睡眠障碍与代谢紊乱有关。代谢综合征（MTS）是一种常见的代谢紊乱综合征，其特征为向心性肥胖、血脂异常、胰岛素抵抗和高血压。 MTS是已知的心肌梗死、中风和肾衰竭的危险因素。到目前为止，还没有研究检查UARS中这些关系，UARS是一种比呼吸暂停更温和的睡眠呼吸障碍。因此，我们假设，在UARS患者中，通过鼻CPAP预防睡眠期间的上气道塌陷将降低表征MTS的参数水平。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this study, we propose to compare the effect of therapeutic nasal CPAP to placebo nasal CPAP on functional complaints of Upper Airway Resistance Syndrome (UARS) patients (i.e., fatigue, daytime sleepiness, sleep problems, gastrointestinal irritability, headache, anxiety and body pain). A goal of this research is to gather pilot data examining the effect of preventing upper airway collapse during sleep upon the metabolic function of UARS patients. Disorders of sleep have been associated with metabolic disorders. One such metabolic disorder, metabolic syndrome (MTS), is a common syndrome characterized by central obesity, dyslipidemia, insulin resistance and hypertension. MTS is known to be a risk factor for myocardial infarction, stroke and renal failure.No research has been conducted to date examining these relationships in UARS, a milder form of sleep disordered breathing than apnea. Therefore, we hypothesize that preventing upper airway collapse during sleep in UARS patients with nasal CPAP will decrease the levels of the parameters that characterize MTS.