INSPIRATORY AIRFLOW DYNAMICS, METABOLIC SYNDROME, AND HYPERAROUSAL IN PATIENTS

患者的吸气气流动力学、代谢综合征和过度觉醒

• 批准号: 7950818
• 负责人: Avram Gold
• 金额: $ 2.1万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7950818
• 关键词: Airway Resistance; Anxiety; Apnea; Central obesity; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Continuous Positive Airway Pressure; Data; Dyslipidemias; Fatigue; Funding; Goals; Grant; Headache; Hypertension; Institution; Insulin Resistance; Kidney; Metabolic; Metabolic Diseases; Metabolic syndrome; Myocardial Infarction; Nose; Pain; Patients; Placebos; Research; Research Personnel; Resources; Risk Factors; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Source; Stroke; Syndrome; Therapeutic Effect; United States National Institutes of Health; gastrointestinal; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this study, we propose to compare the effect of therapeutic nasal CPAP to placebo nasal CPAP on functional complaints of Upper Airway Resistance Syndrome (UARS) patients (i.e., fatigue, daytime sleepiness, sleep problems, gastrointestinal irritability, headache, anxiety and body pain). A goal of this research is to gather pilot data examining the effect of preventing upper airway collapse during sleep upon the metabolic function of UARS patients. Disorders of sleep have been associated with metabolic disorders. One such metabolic disorder, metabolic syndrome (MTS), is a common syndrome characterized by central obesity, dyslipidemia, insulin resistance and hypertension. MTS is known to be a risk factor for myocardial infarction, stroke and renal failure.No research has been conducted to date examining these relationships in UARS, a milder form of sleep disordered breathing than apnea. Therefore, we hypothesize that preventing upper airway collapse during sleep in UARS patients with nasal CPAP will decrease the levels of the parameters that characterize MTS.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 在这项研究中，我们拟比较治疗性经鼻 CPAP 与安慰剂经鼻 CPAP 对上气道阻力综合征 (UARS) 患者功能性主诉（即疲劳、白天嗜睡、睡眠问题、胃肠道烦躁、头痛、焦虑和身体疼痛）的影响。 这项研究的一个目标是收集试点数据，检查预防睡眠期间上呼吸道塌陷对 UARS 患者代谢功能的影响。 睡眠障碍与代谢紊乱有关。其中一种代谢紊乱，代谢综合征（MTS），是一种以中心性肥胖、血脂异常、胰岛素抵抗和高血压为特征的常见综合征。 众所周知，MTS 是心肌梗塞、中风和肾衰竭的危险因素。迄今为止，尚未进行任何研究来检验 UARS（一种比呼吸暂停更轻微的睡眠呼吸障碍）中的这些关系。因此，我们假设，通过经鼻 CPAP 正压通气来预防 UARS 患者睡眠期间上气道塌陷将降低表征 MTS 的参数水平。