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VG 70S-250SEQ HYBRID MASS SPECTROMETER

VG 70S-250SEQ 混合质谱仪

基本信息

批准号：
3520825
负责人：
Avram Gold
金额：
$ 17.7万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
1990
资助国家：
美国
起止时间：
1990-08-01 至 1991-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3520825
关键词：
biomedical equipment resource mass spectrometry

项目摘要

A joint Mass Spectrometry Facility has been created by the Department of Environmental Sciences and Engineering and Chemistry at the University of North Carolina at Chapel Hill. The long-term objectives of the Facility are to support and promote biomedical research and teaching in mass spectrometry at UNC. These objectives will be met by the specific aims of the facility: to encourage the use of mass spectrometry in the health- allied sciences by active interactions with students and faculty; to provide training in mass spectrometry via discussions and hands-on experience; to use mass spectrometry to answer questions crucial to the success of NIH-funded research discussed in more detail under the heading "Description of Research Projects of Major Users". The Facility will provide the capability of identification and structural characterization of important biomolecules, such as nucleosides and oligonucleotides, peptides and steroids as well as synthetic compounds intended for use or testing as pharmaceuticals and biological models. In addition, accessibility to highly flexible, state-of-the-art instrumentation is expected to serve as a catalyst for development of novel applications of mass spectrometry to biomedical research problems by current users and other investigators on campus. This proposal requests funds for partial support of the purchase of a VG 70S-250SEQ Hybrid Mass Spectrometer. This mass spectrometer has the capabilities of electron impact ionization, chemical ionization, fast-atom- bombardment, collisional activation, gas chromatography, high-resolution and accurate-mass measurements. The instrument will be used by NIH-funded and other researchers in the Departments of Biology, biochemistry, Chemistry, Environmental Sciences and Engineering, Medicine and Medicinal Chemistry at the University of North Carolina at Chapel Hill. The Departments of Chemistry and Environmental Sciences and Engineering and Chemistry have committed $300,000 towards the purchase of this instrument with a balance of $327,471.90 to be sought from other sources.

该部门创建了一个联合质谱设施环境科学与工程与化学大学北卡罗来纳州教堂山。该基金的长期目标支持和促进大规模生物医学研究和教学北卡罗来纳大学的光谱测定。这些目标将通过具体目标来实现该设施：鼓励在健康领域使用质谱法通过与学生和教师的积极互动进行联合科学；到通过讨论和实践提供质谱培训经验;使用质谱来回答对 NIH 资助的研究的成功在标题下进行了更详细的讨论 “主要用户研究项目说明”。该设施将提供识别和结构表征的能力重要的生物分子，如核苷和寡核苷酸、肽和类固醇以及用于使用或测试的合成化合物药物和生物模型。此外，可访问性高度灵活、最先进的仪器预计将作为质谱新应用开发的催化剂当前用户和其他研究人员的生物医学研究问题校园。该提案请求资金来部分支持购买 VG 70S-250SEQ 混合质谱仪。该质谱仪具有电子碰撞电离、化学电离、快原子的能力轰击、碰撞活化、气相色谱、高分辨率和精确质量测量。该仪器将由 NIH 资助的以及生物学、生物化学系的其他研究人员，化学、环境科学与工程、医学与药学北卡罗来纳大学教堂山分校化学系。这化学系和环境科学与工程系 Chemistry 承诺投入 300,000 美元购买该仪器余额 327,471.90 美元需从其他来源筹集。