PROTEOMIC ANALYSIS OF PEDIATRIC MULTIPLE SCLEROSIS (MS), A PILOT STUDY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究的目的是确定可能与儿童MS和相关的脱髓鞘疾病的发病机制有关的蛋白质。MS是一种常见于年轻人的中枢神经系统自身免疫性炎症性疾病。然而，0.5-5%的多发性硬化症发生在儿科人群中。 MS的发病机制尚不清楚。目前还没有关于儿科患者蛋白质组学分析的研究发表。我们建议通过检测成人多发性硬化症和儿童多发性硬化症患者的血清蛋白来研究他们之间的可能差异。对这些蛋白质的鉴定可能有助于为该病的诊断确定新的生物标志物，或者可能有助于产生潜在的治疗干预新靶点。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to identify proteins that may be involved in the pathogenesis of MS and related demyelinating disorders of childhood. MS is an autoimmune inflammatory disease of the central nervous system that commonly occurs in young adults. However, 0.5-5 % of MS occurs in the pediatric population. The pathogenesis of MS is yet to be determined. No studies have yet been published regarding the proteomic analysis of pediatric patients. We propose to investigate possible differences between adult and pediatric MS by examining their serum proteins. Identification of these proteins may help identify new biologic markers for the diagnosis of this disease or may help yield potential new targets for therapeutic intervention.