PROTEOMIC ANALYSIS OF PEDIATRIC MULTIPLE SCLEROSIS (MS), A PILOT STUDY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是鉴定可能参与MS和相关儿童脱髓鞘疾病发病机制的蛋白质。MS是一种中枢神经系统的自身免疫性炎症性疾病，通常发生在年轻人中。然而，0.5- 5%的MS发生在儿科人群中。 MS的发病机制尚未确定。 尚未发表关于儿科患者蛋白质组学分析的研究。我们建议通过检查他们的血清蛋白来研究成人和儿童MS之间可能的差异。这些蛋白质的鉴定可能有助于鉴定用于诊断这种疾病的新生物标志物，或者可能有助于产生用于治疗干预的潜在新靶点。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to identify proteins that may be involved in the pathogenesis of MS and related demyelinating disorders of childhood. MS is an autoimmune inflammatory disease of the central nervous system that commonly occurs in young adults. However, 0.5-5 % of MS occurs in the pediatric population. The pathogenesis of MS is yet to be determined. No studies have yet been published regarding the proteomic analysis of pediatric patients. We propose to investigate possible differences between adult and pediatric MS by examining their serum proteins. Identification of these proteins may help identify new biologic markers for the diagnosis of this disease or may help yield potential new targets for therapeutic intervention.