A LONGITUDINAL STUDY OF MILD COGNITIVE IMPAIRMENT IN MS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 认知功能障碍是多发性硬化症残疾的主要原因，造成巨大的社会经济和人际关系损失。不幸的是，多发性硬化症的认知损害过程仍不清楚。这项研究将特别关注目前表现出可测量的认知缺陷的患者，他们仍在从事职业和社会责任。虽然轻度认知损害(MCI)一词已被用来确定老年性痴呆的风险，但我们相信MCI的概念可以应用于特定的MS认知损害患者群体。本项目的目标是评估接受标准临床护理的MS患者的认知恶化过程，并确定这种认知下降的神经放射学和临床相关性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cognitive dysfunction is a leading cause of disability in MS, exacting a tremendous socioeconomic and interpersonal toll. Unfortunately, the course of cognitive impairment in MS remains unclear. This study will focus specifically on patients currently exhibiting measurable cognitive deficits who are still engaged in occupational and social responsibilities. While the term mild cognitive impairment(MCI) has been used to identify elderly patients at risk for the development of Alzheimers disease, we believe the concept of MCI can be applied to a specific group of cognitive impaired patients with MS. The goal of this project is to evaluate the course of cognitive deterioration in MS patients receiving standard clinical care and to identify neuroradiological and clinical correlates of this cognitive decline.