EATING BEHAVIORS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 鉴于肥胖在人的一生中日益流行，了解饮食行为表型及其生理基础变得越来越重要。饮食节制和去抑制相结合是超重女孩和年轻成年女性常见的饮食行为表型。克制是指认知上试图限制进食，去抑制是指失去克制，从而导致暴饮暴食。自我启动的节食尝试在青春期女孩和年轻成年女性中很常见，特别是在超重的人中。女孩和年轻女性试图控制体重往往是医源性的，导致更大的体重增加和饮食紊乱。目前尚不清楚调节食物摄入和饱腹感的荷尔蒙信号的独特特征是否与不同的饮食行为表型有关。同样，饮食行为表型、与食物相关的荷尔蒙信号以及肥胖和代谢综合征的风险因素之间的联系也没有被描述。具体目的是确定进食行为表型在青春期女孩和年轻成年女性中是否具有独特的外周摄食信号动力学。 这些目标将通过在两个测试条件下的行为(约束和去抑制)和外周喂养信号动态来实现，两组包括青春期女孩(n=30；16-17.9岁)和年轻的大学年龄女性(n=30；18-25岁)。青春期女孩和年轻妇女将接受关于测试条件1的下列情况，其中包括食用标准(5-7.5千卡/千克体重)混合餐。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Understanding eating behavior phenotypes and their physiological basis is becoming increasingly important given the rising epidemic of obesity across the lifespan. The combination of dietary restraint and disinhibition is a common eating behavior phenotype among overweight girls and young adult women. Restraint refers to cognitive attempts to limit eating, disinhibition to the loss of restraint, which results in overeating. Self-initiated dieting attempts are common among adolescent girls and young adult women, particularly among those who are overweight. Girls' and young women's attempts at weight control tend to be iatrogenic, resulting in greater weight gain and disordered eating. It is unknown whether unique profiles of the hormonal signals modulating food intake and satiety are associated with distinct eating behavior phenotypes. Likewise, associations between eating behavior phenotypes, food-related hormonal signals, and risk factors for obesity and metabolic syndrome have not been described. The specific aim is to determine if eating behavior phenotypes have unique peripheral feeding signal dynamics in adolescent girls and young adult women. The aims will be accomplished by examining behavioral (restraint and disinhibition) and peripheral feeding signal dynamics during two testing conditions in two groups that include adolescent girls (n=30; 16-17.9 yrs.), and young college-aged women (n=30; 18-25 yrs). The adolescent girls and young women will undergo the following with respect to Test Condition 1, which will involve the consumption of a standardized (5-7.5 kcal/kg body weight) mixed meal.