EATING BEHAVIORS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 了解饮食行为表型及其生理基础变得越来越重要，因为肥胖症在整个生命周期中的流行率不断上升。饮食限制和解除抑制的组合是超重女孩和年轻成年女性中常见的饮食行为表型。克制是指认知上试图限制进食，去抑制是指失去克制，从而导致暴饮暴食。 自我发起的节食尝试在青春期女孩和年轻成年女性中很常见，特别是那些超重的人。 女孩和年轻妇女试图控制体重往往是医源性的，导致体重增加更多和饮食紊乱。目前尚不清楚调节食物摄入和饱腹感的激素信号的独特特征是否与不同的饮食行为表型相关。 同样，饮食行为表型，食物相关的激素信号，肥胖和代谢综合征的风险因素之间的关联尚未被描述。 具体目的是确定饮食行为表型是否在青春期女孩和年轻成年女性中具有独特的外周进食信号动力学。 通过在两个测试条件下检查包括青春期女孩（n=30; 16-17.9岁）的两组中的行为（抑制和去抑制）和外周进食信号动力学来实现目标，和年轻的大学年龄女性（n=30; 18-25岁）。青春期女孩和年轻女性将接受以下关于测试条件1的测试，这将涉及食用标准化（5-7.5 kcal/kg体重）混合餐。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Understanding eating behavior phenotypes and their physiological basis is becoming increasingly important given the rising epidemic of obesity across the lifespan. The combination of dietary restraint and disinhibition is a common eating behavior phenotype among overweight girls and young adult women. Restraint refers to cognitive attempts to limit eating, disinhibition to the loss of restraint, which results in overeating. Self-initiated dieting attempts are common among adolescent girls and young adult women, particularly among those who are overweight. Girls' and young women's attempts at weight control tend to be iatrogenic, resulting in greater weight gain and disordered eating. It is unknown whether unique profiles of the hormonal signals modulating food intake and satiety are associated with distinct eating behavior phenotypes. Likewise, associations between eating behavior phenotypes, food-related hormonal signals, and risk factors for obesity and metabolic syndrome have not been described. The specific aim is to determine if eating behavior phenotypes have unique peripheral feeding signal dynamics in adolescent girls and young adult women. The aims will be accomplished by examining behavioral (restraint and disinhibition) and peripheral feeding signal dynamics during two testing conditions in two groups that include adolescent girls (n=30; 16-17.9 yrs.), and young college-aged women (n=30; 18-25 yrs). The adolescent girls and young women will undergo the following with respect to Test Condition 1, which will involve the consumption of a standardized (5-7.5 kcal/kg body weight) mixed meal.