REFUEL

加油

• 批准号: 7951338
• 负责人: Mary Jane De Souza
• 金额: $ 11.14万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951338
• 关键词: Body Weight; Body fat; Bone Density; Bone Resorption; Chronic; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Eating; Effectiveness; Energy Intake; Estrogens; Exercise; Exhibits; Fracture; Funding; Grant; Institution; Intervention; Measurement; Menstrual cycle; Menstruation; Outcome; Pathway interactions; Relative (related person); Research; Research Personnel; Resources; Risk; Source; Testing; Translating; United States National Institutes of Health; Weight Gain; Woman; bone; bone health; energy balance; food restriction; improved

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall purpose of this study is to test the effectiveness of 12 months of increased food intake to improve bone health and restore menstrual cycles in women with menstrual disturbances who exercise regularly and exhibit chronic energy deficiency. We will determine the following: 1) if an increased caloric intake intervention that results in an energy surplus and weight gain in women with Exerciseassociated menstrual disturbances (EAMD) and low to normal bone mineral density (BMD) reverses the deleterious effects of food restriction and negative energy balance on bone outcomes; 2) the relative contributions of estrogen-dependent and estrogen-independent pathways to bone outcomes; 3) if any improved effects of estrogen status or markers of bone resorption or formation translate into detectable changes in improved bone outcomes, as assessed by serial dual energy x-ray absorptiometry (DXA) and pQCT measurements, that may impact fracture risk; and 4) the relative contribution of changes in body weight, body fat and lean mass to BMD and resumption of menses.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的总体目的是测试12个月的增加食物摄入量对改善骨骼健康和恢复月经周期的有效性，这些女性患有月经失调，经常锻炼并表现出慢性能量缺乏。我们将确定以下内容：1）增加热量摄入的干预，导致能量过剩和体重增加的妇女与月经失调（EAMD）和低至正常的骨矿物质密度（BMD）逆转食物限制和负能量平衡对骨结果的有害影响; 2）雌激素依赖性和雌激素非依赖性途径对骨结果的相对贡献; 3）雌激素状态或骨吸收或形成的标志物的任何改善的效果是否转化为改善的骨结果的可检测的变化，如通过连续双能X射线吸收测定法（DXA）和pQCT测量所评估的，其可能影响骨折风险;和4）体重、体脂和瘦体重的变化对BMD和月经恢复的相对贡献。