TYPE 1 DIABETES GENETICS CONSORTIUM

1 型糖尿病遗传学联盟

• 批准号: 7951924
• 负责人: PHYLLIS W SPEISER
• 金额: $ 0.17万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951924
• 关键词: Affect; Area; Autoimmune Diseases; CTLA4 gene; Child; Chromosome Mapping; Clinical; Clinical Research; Communities; Computer Retrieval of Information on Scientific Projects Database; DNA; Databases; Family; Funding; Genes; Genetic; Genetic Risk; Genetic Structures; Genome; Goals; Grant; Individual; Institution; Insulin-Dependent Diabetes Mellitus; International; Medical History; Methods; Prevention therapy; Research; Research Personnel; Resources; Risk; Source; Susceptibility Gene; United States National Institutes of Health; diabetes mellitus genetics; repository; type I diabetic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of the Consortium is to organize international efforts to identify genes that determine an individual's risk of type 1 diabetes. 1. To ascertain, study and establish a renewable source of DNA on 3000 families with at least two Type 1 diabetic children for studies to map genes that affect the genetic risk for Type 1 diabetes (affected sib-pair families); 2. To create a database for the scientific community with clinical, genetic (HLA, CTLA4, genome screen), and medical history information that would facilitate the search for Type 1 diabetes susceptibility genes; 3. To provide a centralized DNA repository to allow targeted studies of genetic structure and function for Type 1 diabetes, its complications, and other autoimmune diseases; 4. To evaluate opportunities to extend the results of research to develop methods of risk prediction, prevention and therapy in the area of Type 1 diabetes, its complications, and other autoimmune diseases.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该联盟的目标是组织国际努力来识别决定个人患 1 型糖尿病风险的基因。 1. 确定、研究并建立 3000 个至少有两名 1 型糖尿病儿童的家庭的可再生 DNA 来源，用于研究绘制影响 1 型糖尿病遗传风险的基因图谱（受影响的同胞对家庭）； 2. 为科学界创建一个包含临床、遗传（HLA、CTLA4、基因组筛查）和病史信息的数据库，以方便寻找 1 型糖尿病易感基因； 3. 提供集中的DNA存储库，以便对1型糖尿病、其并发症和其他自身免疫性疾病的遗传结构和功能进行有针对性的研究； 4. 评估扩展研究成果的机会，以开发 1 型糖尿病、其并发症和其他自身免疫性疾病领域的风险预测、预防和治疗方法。