TYPE 1 DIABETES GENETICS CONSORTIUM

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该联盟的目标是组织国际努力，以确定决定个人患1型糖尿病风险的基因。 1.确定、研究和建立至少有两个1型糖尿病儿童的3000个家庭的可再生DNA来源，用于研究影响1型糖尿病遗传风险的基因(受影响的同胞对家庭)； 2.为科学界创建一个包含临床、遗传(人类白细胞抗原、CTLA4、基因组筛选)和病史信息的数据库，以促进对1型糖尿病易感基因的搜索； 3.提供中央DNA资料库，以便对1型糖尿病及其并发症和其他自身免疫性疾病的遗传结构和功能进行有针对性的研究； 4.评估扩大研究成果的机会，以开发1型糖尿病、其并发症和其他自身免疫性疾病领域的风险预测、预防和治疗方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of the Consortium is to organize international efforts to identify genes that determine an individual's risk of type 1 diabetes. 1. To ascertain, study and establish a renewable source of DNA on 3000 families with at least two Type 1 diabetic children for studies to map genes that affect the genetic risk for Type 1 diabetes (affected sib-pair families); 2. To create a database for the scientific community with clinical, genetic (HLA, CTLA4, genome screen), and medical history information that would facilitate the search for Type 1 diabetes susceptibility genes; 3. To provide a centralized DNA repository to allow targeted studies of genetic structure and function for Type 1 diabetes, its complications, and other autoimmune diseases; 4. To evaluate opportunities to extend the results of research to develop methods of risk prediction, prevention and therapy in the area of Type 1 diabetes, its complications, and other autoimmune diseases.