PROTEOMICS OF CEREBROSPINAL FLUID IN CFS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 神经功能障碍是慢性疲劳综合征(CFS)、纤维肌痛(FM)和其他相关疾病的临床表现和病例设计的关键组成部分。如果中枢神经系统受累，则脑脊液中将有证据。与健康对照(HC)受试者相比，慢性疲劳综合征(CFS)患者体内存在不同的蛋白质模式。我们研究中的其他测试包括：1.肺容量的评估和呼吸测试引起的呼吸短促的评分，也称为肺功能测试(PFT)。2.比较握手运动试验前后的血压和心率反应。3.皮肤测试，如i)辣椒素皮肤测试，检查不同剂量的辣椒素(辣椒精华)对前臂的特殊反应，如灼烧感、皮肤发红面积、瘙痒感，并比较CFS组和健康对照组的反应是否有任何差异。Ii)过敏皮肤测试，以查看在CFS人群中是否有任何过敏。4.18压痛点测试，比较腰椎穿刺术前后的痛阈值，也称为脊椎抽液。18压痛点试验是纤维肌痛的一种诊断试验。5.许多患有CFS的参与者确实有与偏头痛相关的头痛，他们抱怨说，严重的光敏感和大声的噪音可能会让他们头痛。我们正在分析这些人，必须决定哪些药物最好起作用，并立即缓解这些参与者的头痛。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Neurological dysfunction is a key component of the clinical expression and case designation of chronic fatigue syndrome (CFS), fibromyalgia (FM)and other related conditions.If the central nervous system is involved, then evidence will be present in the cerebrospinal fluid. Distinct patterns of proteins will be present in Chronic fatigue syndrome (CFS) compared to healthy control (HC) subjects. Other testing in our study would include,1. Assessment of lung capacity and scoring the shortness of breath as a result of breathing testing also called as the Pulmonary function testing (PFT). 2. Compare the blood pressure and heart rate response before and after hand grip exercise testing. 3. Skin tests like the i) Capsaicin skin test, to check for specific responses like burning sensation, area of skin redness, itchy sensation to varying doses of capsaicin (essence of chilli pepper), when placed on the forearm and to compare if there are any differences seen between the responses in CFS and Healthy controls. ii) Allergy skin test to look if there are any allergies that are seen in the set of CFS population. 4. 18 tenderness point testing to compare the pain threshold before and after the lumbar puncture also know as the spinal tap. 18 tenderness point testing is a diagnostic test for Fibromyalgia. 5. Many of the participants with CFS do have associated Migraine headaches and they complain of severe light sensitivity and loud noises could give them headache. We are analysing those group of people and decision have to be made as to which medications would work at best and give them immediate relief from headache in these group of participants.