PROTEOMICS OF CEREBROSPINAL FLUID IN CFS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 神经功能障碍是慢性疲劳综合征（CFS）、纤维肌痛（FM）和其他相关疾病的临床表现和病例名称的关键组成部分。如果涉及中枢神经系统，则脑脊液中会出现证据。与健康对照（HC）受试者相比，慢性疲劳综合征（CFS）中存在不同的蛋白质模式。 我们研究中的其他测试包括，1.评估肺活量并对呼吸短促进行评分，作为呼吸测试的结果，也称为肺功能测试（PFT）。2.比较握力运动试验前后的血压和心率反应。3.皮肤测试，如i）辣椒素皮肤测试，以检查对不同剂量的辣椒素（辣椒精）的特定反应，如烧灼感，皮肤发红区域，瘙痒感，当放置在前臂上时，并比较CFS和健康对照组的反应之间是否存在任何差异。ii）过敏皮肤测试，以查看CFS人群中是否有任何过敏。4. 18.压痛点测试，比较腰椎穿刺前后的痛阈也称为脊椎穿刺。18压痛点测试是纤维肌痛的诊断测试。5.许多患有CFS的参与者确实有相关的偏头痛，他们抱怨严重的光敏感性和巨大的噪音可能会让他们头痛。我们正在分析这些人群，并决定哪些药物最有效，并立即缓解这些参与者的头痛。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Neurological dysfunction is a key component of the clinical expression and case designation of chronic fatigue syndrome (CFS), fibromyalgia (FM)and other related conditions.If the central nervous system is involved, then evidence will be present in the cerebrospinal fluid. Distinct patterns of proteins will be present in Chronic fatigue syndrome (CFS) compared to healthy control (HC) subjects. Other testing in our study would include,1. Assessment of lung capacity and scoring the shortness of breath as a result of breathing testing also called as the Pulmonary function testing (PFT). 2. Compare the blood pressure and heart rate response before and after hand grip exercise testing. 3. Skin tests like the i) Capsaicin skin test, to check for specific responses like burning sensation, area of skin redness, itchy sensation to varying doses of capsaicin (essence of chilli pepper), when placed on the forearm and to compare if there are any differences seen between the responses in CFS and Healthy controls. ii) Allergy skin test to look if there are any allergies that are seen in the set of CFS population. 4. 18 tenderness point testing to compare the pain threshold before and after the lumbar puncture also know as the spinal tap. 18 tenderness point testing is a diagnostic test for Fibromyalgia. 5. Many of the participants with CFS do have associated Migraine headaches and they complain of severe light sensitivity and loud noises could give them headache. We are analysing those group of people and decision have to be made as to which medications would work at best and give them immediate relief from headache in these group of participants.