PROTEOMICS OF CEREBROSPINAL FLUID IN CFS

CFS 脑脊液蛋白质组学

• 批准号: 7719067
• 负责人: JAMES N BARANIUK
• 金额: $ 5.56万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719067
• 关键词: Academic Medical Centers; Brain; Cerebrospinal Fluid; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Diagnostic; Disease; Fibromyalgia; Funding; Grant; Gulf War; Health; Institution; Liquid substance; Molecular; Persian Gulf; Proteins; Proteomics; Recruitment Activity; Research; Research Personnel; Resources; Set protein; Source; Spinal Puncture; Spinal Tap; Syndrome; Testing; United States National Institutes of Health; Woman; healthy volunteer; insight; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have performed lumbar punctures ("spinal taps") on CFS, fibromyalgia (FM), and Persian Gulf War Illness (PGI) subjects and a group of healthy volunteers. The CFS and related groups had a unique set of proteins in the fluid surrounding their brains. This is very exciting because it is strong evidence that CFS, FM, and PGI are "real" diseases. The proteins we found may turn out to be diagnostic markers for these syndromes, and become part of a test for CFS/FM/PGI illnesses. They also offer insights into the molecular mechanisms that go awry, and point towards potential treatments. First, however, we must perform more spinal taps on women with CFS and health control women. We offer a new, paid, clinical research study with a 1 night stay at Georgetown University Medical Center, lumbar puncture and other, more simple tests. We are recruiting 50 women with CFS and 50 healthy women who want to help find a cure.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们对CFS、纤维肌痛（FM）和波斯湾战争疾病（PGI）受试者和一组健康志愿者进行了腰椎穿刺（“脊椎穿刺”）。CFS和相关组在他们大脑周围的液体中有一组独特的蛋白质。这是非常令人兴奋的，因为它是强有力的证据表明，CFS，FM和PGI是“真实的”疾病。我们发现的蛋白质可能成为这些综合征的诊断标志物，并成为CFS/FM/PGI疾病测试的一部分。它们还提供了对出错的分子机制的见解，并指出了潜在的治疗方法。然而，首先，我们必须对CFS妇女和健康对照妇女进行更多的脊椎穿刺。 我们提供一个新的，付费的，临床研究研究，在乔治敦大学医学中心住一晚，腰椎穿刺和其他更简单的测试。我们正在招募50名CFS女性和50名健康女性，她们希望帮助找到治愈方法。