KETOROLAC AND ASPIRIN DESENSITIZATION (KAD)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目的是确定酮咯酸鼻腔刺激是否预测口服阿司匹林挑战的反应。这项研究被称为“先导性”研究，因为我们将评估酮咯酸鼻腔刺激剂预测阿司匹林脱敏结果的能力。如果酮咯酸测试是预测性的，那么我们可以使阿司匹林脱敏更安全。之所以进行这项研究，是因为目前阿司匹林脱敏的方法可能需要几天时间，可能会导致严重的哮喘发作。酮咯酸的鼻部刺激可能会预测你是否更有可能出现这些严重的阿司匹林反应之一。因此，这种新方法可能比其他方法更安全，耗时更短。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine if ketorolac nasal provocation predicts reactions to oral aspirin challenge. This is called a "pilot" study because we will assess the ability of the ketorolac nasal provocation to predict the results of the aspirin desensitization. If the ketorolac testing is predictive, then we can make the aspirin desensitization safer. This research is being done because current methods for aspirin desensitization can take several days and may lead to severe asthma attacks. The ketorolac nasal provocation may predict if you are more likely to have one of these severe aspirin reactions. Therefore, this new method may be safer and take less time than other methods.