KETOROLAC AND ASPIRIN DESENSITIZATION (KAD)

酮咯酸和阿司匹林脱敏 (KAD)

• 批准号: 7952019
• 负责人: JAMES N BARANIUK
• 金额: $ 0.17万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7952019
• 关键词: Aspirin; Asthma; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Institution; Ketorolac; Lead; Methods; Nose; Oral; Pilot Projects; Reaction; Research; Research Personnel; Resources; Source; Testing; Time; United States National Institutes of Health; desensitization

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine if ketorolac nasal provocation predicts reactions to oral aspirin challenge. This is called a "pilot" study because we will assess the ability of the ketorolac nasal provocation to predict the results of the aspirin desensitization. If the ketorolac testing is predictive, then we can make the aspirin desensitization safer. This research is being done because current methods for aspirin desensitization can take several days and may lead to severe asthma attacks. The ketorolac nasal provocation may predict if you are more likely to have one of these severe aspirin reactions. Therefore, this new method may be safer and take less time than other methods.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是确定酮咯酸鼻腔激发是否可预测口服阿司匹林激发的反应。 这被称为“先导”研究，因为我们将评估酮咯酸鼻激发预测阿司匹林脱敏结果的能力。 如果酮咯酸测试是预测性的，那么我们可以使阿司匹林脱敏更安全。 这项研究正在进行，因为目前的阿司匹林脱敏方法可能需要几天时间，并可能导致严重的哮喘发作。 酮咯酸鼻腔激发可以预测您是否更有可能发生这些严重的阿司匹林反应之一。 因此，这种新方法可能比其他方法更安全，花费更少的时间。