THE MOLECULAR BASIS FOR COGNITIVE IMPAIRMENT IN PARKINSON'S DISEASE: A PET STUDY

帕金森病认知障碍的分子基础：宠物研究

• 批准号: 7951927
• 负责人: ANDREW FEIGIN
• 金额: $ 0.03万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951927
• 关键词: Clinical Research; Cognitive deficits; Computer Retrieval of Information on Scientific Projects Database; Deposition; Disease; Functional disorder; Funding; Grant; Image; Impaired cognition; Institution; Lewy Bodies; Metabolic; Molecular; Parkinson Disease; Patients; Positron-Emission Tomography; Research; Research Personnel; Resources; Source; Tracer; United States National Institutes of Health; base; novel; protein aggregate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cognitive deficits occur in Parkinson's disease (PD) and the cause is currently unknown. We propose a novel study utilizing multi-tracer positron emission tomography (PET) imaging to investigate the pathophysiology of cognitive impairment in non-demented PD patients. We hypothesize that aggregated protein deposits associated with Lewy body in the cortical regions may correlate with abnormal metabolic activity and underlie cognitive dysfunction.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 认知缺陷发生在帕金森氏病（PD）中，原因目前尚不清楚。我们提出了一项利用多跟踪正电子发射断层扫描（PET）成像的新研究，以研究非痴呆的PD患者认知障碍的病理生理学。我们假设在皮质区域与Lewy体相关的汇总蛋白沉积物可能与异常的代谢活性和认知功能障碍基础有关。