THE MOLECULAR BASIS FOR COGNITIVE IMPAIRMENT IN PARKINSON'S DISEASE: A PET STUDY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，但不一定是研究者所在的机构。 认知缺陷发生在帕金森病（PD）中，其原因目前尚不清楚。我们提出了一项新的研究，利用多示踪剂正电子发射断层扫描（PET）成像，以调查非痴呆PD患者的认知功能障碍的病理生理学。我们推测，皮质区域与路易体相关的聚集蛋白沉积可能与异常代谢活动相关，并成为认知功能障碍的基础。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cognitive deficits occur in Parkinson's disease (PD) and the cause is currently unknown. We propose a novel study utilizing multi-tracer positron emission tomography (PET) imaging to investigate the pathophysiology of cognitive impairment in non-demented PD patients. We hypothesize that aggregated protein deposits associated with Lewy body in the cortical regions may correlate with abnormal metabolic activity and underlie cognitive dysfunction.