THE MOLECULAR BASIS FOR COGNITIVE IMPAIRMENT IN PARKINSON'S DISEASE: A PET STUDY

帕金森病认知障碍的分子基础：宠物研究

• 批准号: 7951927
• 负责人: ANDREW FEIGIN
• 金额: $ 0.03万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951927
• 关键词: Clinical Research; Cognitive deficits; Computer Retrieval of Information on Scientific Projects Database; Deposition; Disease; Functional disorder; Funding; Grant; Image; Impaired cognition; Institution; Lewy Bodies; Metabolic; Molecular; Parkinson Disease; Patients; Positron-Emission Tomography; Research; Research Personnel; Resources; Source; Tracer; United States National Institutes of Health; base; novel; protein aggregate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cognitive deficits occur in Parkinson's disease (PD) and the cause is currently unknown. We propose a novel study utilizing multi-tracer positron emission tomography (PET) imaging to investigate the pathophysiology of cognitive impairment in non-demented PD patients. We hypothesize that aggregated protein deposits associated with Lewy body in the cortical regions may correlate with abnormal metabolic activity and underlie cognitive dysfunction.

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