METABOLIC CORRELATES OF PEDUNCULOPONTINE NUCLEUS DEEP BRAIN STIMULATION IN PD

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 本研究将利用先进的成像方法来阐明帕金森病患者的脚桥核脑深部电刺激的临床效果的神经生理机制。 除了提供有关正常脑功能以及帕金森病如何改变的有价值的信息外，拟议的研究还将提供有关临床实践中该手术患者选择的实用信息。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will utilize advanced imaging methods to elucidate the neurophysiological mechanisms underlying the clinical effects of pedunculopontine nucleus deep brain stimulation in patients with Parkinson's disease. In addition to providing valuable information regarding normal brain function and how this is altered in Parkinson's disease, the proposed study will provide practically useful information regarding patient selection for this procedure in clinical practice.