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PHOSPHORYLATION REGULATES HUMAN CDC5 FUNCTION

PHOSPHORYLATION REGULATES HUMAN CDC5 FUNCTION
磷酸化调节人类 CDC5 功能
批准号：
7957368
负责人：
HAROLD S BERNSTEIN
金额：
$0.01万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-06-01 至 2010-05-31
来源：
https://reporter.nih.gov/project-details/7957368
关键词：
CellsComputer Retrieval of Information on Scientific Projects DatabaseDataFundingGrantHumanInstitutionMammalian CellMapsMass Spectrum AnalysisPhosphorylationPhosphorylation SiteResearchResearch PersonnelResourcesRoleSerumSourceTestingUnited States National Institutes of Healthmutant

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中文摘要
翻译
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Human CDC5 (hCDC5) is an important regulator of G2/M in mammalian cells. It is rapidly phosphorylated upon serum stimulation of cells, and we propose that phosphorylation regulates hCDC5 function. We seek to employ mass spectrometry to map the phosphorylation sites in hCDC5. We will use these data to make phosphospecific mutants and test their role in hCDC5 function.
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PHOSPHORYLATION REGULATES HUMAN CDC5 FUNCTION