课题基金 / 基金详情

THROMBIN RECEPTOR MEDIATED SIGNAL TRANSDUCTION

THROMBIN RECEPTOR MEDIATED SIGNAL TRANSDUCTION
凝血酶受体介导的信号转导
批准号：
2734935
负责人：
HAROLD S BERNSTEIN
金额：
$8.07万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1995
资助国家：
美国
项目状态：
已结题
起止时间：
1995-07-01 至 2000-06-30
来源：
https://reporter.nih.gov/project-details/2734935
关键词：
G protein Xenopus oocyte antisense nucleic acid biological signal transduction blocking antibody chemical kinetics chimeric proteins enzyme activity gene expression intermolecular interaction intracellular mitogen activated protein kinase molecular site mutant oligonucleotides peptide analog precipitation protein structure receptor receptor coupling receptor expression thrombin tissue /cell culture vascular endothelium western blottings

项目摘要

项目成果

HAROLD S BERNSTEIN的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
The research plan proposes the characterization of intracellular mechanisms by which the cloned thrombin receptor mediates multiple cellular activities. Specifically, the candidate will: 1) identify G proteins which mediate thrombin signaling; 2) determine the functional sites for receptor-G protein interaction; and 3) define the cloned thrombin receptor's role in thrombin-induced activation of intracellular kinase cascades. These studies will allow the candidate to develop expertise in methodologies used to interrogate receptor-mediated signal transduction including: receptor expression in somatic cell and oocyte systems; chimeric receptor engineering; G protein binding assays; MAPK, Raf, and Ras activity assays; and the use of dominant negative mutants to explore the function of various signaling elements.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
PHOSPHORYLATION REGULATES HUMAN CDC5 FUNCTION
Stem Cell Differentiation for Myocardial Therapy
Stem Cell Differentiation for Myocardial Therapy
STEM CELL ANTIGEN-1-INTERACTING PROTEINS
海外基金