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THROMBIN RECEPTOR MEDIATED SIGNAL TRANSDUCTION

THROMBIN RECEPTOR MEDIATED SIGNAL TRANSDUCTION
凝血酶受体介导的信号转导
批准号：
2445014
负责人：
HAROLD S BERNSTEIN
金额：
$8.07万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1995
资助国家：
美国
项目状态：
已结题
起止时间：
1995-07-01 至 2000-06-30
来源：
https://reporter.nih.gov/project-details/2445014
关键词：
G protein Xenopus oocyte antisense nucleic acid biological signal transduction blocking antibody chemical kinetics chimeric proteins enzyme activity gene expression intermolecular interaction intracellular mitogen activated protein kinase molecular site mutant oligonucleotides peptide analog precipitation protein structure receptor receptor coupling receptor expression thrombin tissue /cell culture vascular endothelium western blottings

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英文摘要
The research plan proposes the characterization of intracellular mechanisms by which the cloned thrombin receptor mediates multiple cellular activities. Specifically, the candidate will: 1) identify G proteins which mediate thrombin signaling; 2) determine the functional sites for receptor-G protein interaction; and 3) define the cloned thrombin receptor's role in thrombin-induced activation of intracellular kinase cascades. These studies will allow the candidate to develop expertise in methodologies used to interrogate receptor-mediated signal transduction including: receptor expression in somatic cell and oocyte systems; chimeric receptor engineering; G protein binding assays; MAPK, Raf, and Ras activity assays; and the use of dominant negative mutants to explore the function of various signaling elements.
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