ROUTINE NMR FOR CHARACTERIZATION OF ORGANIC COMPOUNDS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 蛋白质的氨基酸序列编码其三维结构，并且这种结构在生物学功能中表现出来。利用从合成化学到生物化学再到细胞生物学的技术，Raines小组正在阐明蛋白质结构和蛋白质功能的化学基础和生物学目的。Raines小组的努力使人们深入了解氨基酸序列与蛋白质功能（或功能障碍）之间的关系，以及创造具有理想特性的新型分子。这涉及用于蛋白质修饰、蛋白质/肽合成和物理有机研究的有机小分子的合成。质子，碳和磷核磁共振实验需要这些小的有机分子的特性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The amino acid sequence of a protein encodes its three-dimensional structure, and this structure manifests itself in biological function. Using techniques that range from synthetic chemistry to biochemistry to cell biology, the Raines group is illuminating in atomic detail both the chemical basis and the biological purpose for protein structure and protein function. The efforts of the Raines group are leading to insights into the relationship between amino acid sequence and protein function (or dysfunction), as well as to the creation of novel molecules with desirable properties. This involves syntheses of small organic molecules for protein modification, protein/peptide synthesis and physical organic studies. Proton, carbon and phosphorus NMR experiments are required for characterization of these small organic molecules.