ROUTINE NMR FOR CHARACTERIZATION OF ORGANIC COMPOUNDS

用于表征有机化合物的常规 NMR

• 批准号: 8168934
• 负责人: Ronald T Raines
• 金额: $ 1.39万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168934
• 关键词: Amino Acid Sequence; Biochemistry; Biological; Biological Process; Carbon; Cellular biology; Chemicals; Computer Retrieval of Information on Scientific Projects Database; Functional disorder; Funding; Grant; Institution; Peptide Synthesis; Phosphorus; Post-Translational Protein Processing; Property; Proteins; Protons; Research; Research Personnel; Resources; Source; Structure; Synthesis Chemistry; Techniques; United States National Institutes of Health; base; insight; novel; protein function; protein structure; research study; three dimensional structure

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The amino acid sequence of a protein encodes its three-dimensional structure, and this structure manifests itself in biological function. Using techniques that range from synthetic chemistry to biochemistry to cell biology, the Raines group is illuminating in atomic detail both the chemical basis and the biological purpose for protein structure and protein function. The efforts of the Raines group are leading to insights into the relationship between amino acid sequence and protein function (or dysfunction), as well as to the creation of novel molecules with desirable properties. This involves syntheses of small organic molecules for protein modification, protein/peptide synthesis and physical organic studies. Proton, carbon and phosphorus NMR experiments are required for characterization of these small organic molecules.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 蛋白质的氨基酸序列编码其三维结构，这种结构体现在生物功能上。利用从合成化学到生物化学再到细胞生物学的各种技术，Raines团队正在从原子细节上阐明蛋白质结构和功能的化学基础和生物学目的。Raines小组的努力正在深入了解氨基酸序列与蛋白质功能(或功能障碍)之间的关系，并创造出具有理想特性的新分子。这包括用于蛋白质修饰、蛋白质/肽合成和物理有机研究的有机小分子的合成。要对这些有机小分子进行表征，需要进行质子、碳和磷核磁共振实验。