CELL FREE HEMOGLOBIN EFFECT ON ORGAN BLOOD FLOW

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 使用Sprague Dawly大鼠，8-11周，300克，该研究的目的是在用3 ml基于血红蛋白的氧载体“氧珠蛋白”或载体对照（盐水）处理后2和4小时测定动物的肾、肺和脑中的血流量。 我们想确定用氧珠蛋白治疗观察到的心输出量的减少是否反映了相应的血流量和向各种器官床输送氧气的减少。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Using Sprague Dawly rats, 8-11 weeks, 300 grams, the aims of the study are to determine blood flow in the kidney, pulmonary and brain in animals at 2 and 4 hours after being treated with either 3 ml of the hemoglobin-based oxygen carrier "Oxyglobin" or the vehicle control (saline). We want to determine if the decrease in cardiac output observed with Oxyglobin treament reflects a corresponding decrease in blood flow and oxygen delivery to various organ beds.