CELL FREE HEMOGLOBIN EFFECT ON ORGAN BLOOD FLOW

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 使用体重为300克、8-11周的SpragueDawly大鼠，研究的目的是在动物接受3毫升基于血红蛋白的氧气载体“氧珠蛋白”或赋形剂对照组(生理盐水)治疗2小时和4小时后，测定动物肾脏、肺和脑中的血流量。 我们想要确定用氧珠蛋白治疗观察到的心输出量的减少是否反映了相应的血流和向不同器官床的氧气输送的减少。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Using Sprague Dawly rats, 8-11 weeks, 300 grams, the aims of the study are to determine blood flow in the kidney, pulmonary and brain in animals at 2 and 4 hours after being treated with either 3 ml of the hemoglobin-based oxygen carrier "Oxyglobin" or the vehicle control (saline). We want to determine if the decrease in cardiac output observed with Oxyglobin treament reflects a corresponding decrease in blood flow and oxygen delivery to various organ beds.