TECHNIQUES FOR T1P-WEIGHTED IMAGING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 磁共振(MR)图像中的常规对比度来自于1H磁弛豫 组织的特性。纵向磁弛豫(T1)和横向磁弛豫值的变化 松弛(T2)区分健康状态和病理状态。非同寻常的对比 基于旋转标架自旋-晶格驰豫时间T1p的机制对 人类乳房病变状态，大鼠早期急性脑缺血，软骨 骨关节炎、创伤后软骨损伤和腰椎管狭窄时的退行性变 与退行性间盘疾病有关的间盘。此外，功能性T1p成像 显示了增强的粗体信号和对间接检测到的代谢的改进响应 氧气-17号水。这个子项目的目的是开发T1p加权的技术 影像学既强调新的方法，又强调向临床的转化。 新方法： 1.通过非共振旋转回波磁化对B1场不均匀的校正 准备脉冲序列。 2.通过集成自旋回波和自旋锁定来修正B0和B1场的不均匀性 磁化准备脉冲序列。 3.集成自旋锁定和平衡梯度回波的稳态自旋锁定技术 脉冲序列设计。 翻译到临床的方法： 1.T1p准备，中心重新排序的平衡梯度回波成像，用于快速3D T1p加权 图像采集。 2.利用导航仪回波进行运动校正。 3.结合部分傅里叶和并行成像的Kspace捕获，用于图像模糊抑制和 缩短了获取时间。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Conventional contrast in magnetic resonance (MR) images derives from the 1H magnetic relaxation properties of tissues. Variations in longitudinal magnetic relaxation (T1) and transverse magnetic relaxation (T2) distinguish the healthy and pathological states. An unconventional contrast mechanism based on the rotating frame spin-lattice relaxation time T1p shows sensitivity to the diseased states of the human breast, early acute cerebral ischemia in rats, cartilage degeneration during osteoarthritis, posttraumatic cartilage injury and narrowing of lumbar intervertebral discs associated with degenerative disc disease. In addition, functional T1p imaging shows both an augmented BOLD signal and improved response to indirectly detected metabolic oxygen-17 water. The purpose of this subproject is to develop techniques for T1p-weighted imaging emphasizing both novel methods and translation to the clinic. Novel Methods: 1. Correction for B1 field inhomogeneity by an off-resonance rotary echo magnetization preparation pulse sequence. 2. Correction for B0 and B1 field inhomogeneity by an integrated spin echo and spin lock magnetization preparation pulse sequence. 3. Steady-state spin lock techniques by integrated spin lock and balanced gradient echo pulse sequence design. Methods for Translation to the Clinic: 1. T1p-prepared, centrically reordered balanced gradient echo imaging for rapid 3D T1p-weighted image acquisition. 2. Motion correction by navigator echoes. 3. Integrated partial Fourier and parallel imaging kspace acquisition for image blur reduction and reduced acquisition time.