TECHNIQUES FOR T1P-WEIGHTED IMAGING

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 磁共振（MR）图像中的常规对比度源自1H磁弛豫 组织的性质。纵向磁弛豫（T1）和横向磁弛豫（T2）的变化 松弛（T2）区分健康和病理状态。一个非传统的对比 基于旋转坐标系自旋-晶格弛豫时间T1 p的机制显示出对 人乳腺疾病状态，大鼠早期急性脑缺血，软骨 骨关节炎期间的退变、创伤后软骨损伤和腰椎狭窄 与退行性椎间盘疾病相关的椎间盘。此外，功能性T1 p成像 显示了增强的BOLD信号和对间接检测到的代谢产物的改善的响应。 氧-17水。 该子项目的目的是开发T1 p加权技术， 影像学强调新方法和临床应用。 新方法： 1.非共振旋转回波磁化对B1场不均匀性的校正 准备脉冲序列。 2.用集成自旋回波和自旋锁校正B 0和B1场的不均匀性 磁化准备脉冲序列。 3.通过集成自旋锁和平衡梯度回波的稳态自旋锁技术 脉冲序列设计 翻译到诊所的方法： 1.快速3D T1 p加权的T1 p准备、中心重排平衡梯度回波成像 图像采集 2.通过导航回波进行运动校正。 3.集成的部分傅立叶和并行成像kspace采集，用于减少图像模糊， 缩短采集时间。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Conventional contrast in magnetic resonance (MR) images derives from the 1H magnetic relaxation properties of tissues. Variations in longitudinal magnetic relaxation (T1) and transverse magnetic relaxation (T2) distinguish the healthy and pathological states. An unconventional contrast mechanism based on the rotating frame spin-lattice relaxation time T1p shows sensitivity to the diseased states of the human breast, early acute cerebral ischemia in rats, cartilage degeneration during osteoarthritis, posttraumatic cartilage injury and narrowing of lumbar intervertebral discs associated with degenerative disc disease. In addition, functional T1p imaging shows both an augmented BOLD signal and improved response to indirectly detected metabolic oxygen-17 water. The purpose of this subproject is to develop techniques for T1p-weighted imaging emphasizing both novel methods and translation to the clinic. Novel Methods: 1. Correction for B1 field inhomogeneity by an off-resonance rotary echo magnetization preparation pulse sequence. 2. Correction for B0 and B1 field inhomogeneity by an integrated spin echo and spin lock magnetization preparation pulse sequence. 3. Steady-state spin lock techniques by integrated spin lock and balanced gradient echo pulse sequence design. Methods for Translation to the Clinic: 1. T1p-prepared, centrically reordered balanced gradient echo imaging for rapid 3D T1p-weighted image acquisition. 2. Motion correction by navigator echoes. 3. Integrated partial Fourier and parallel imaging kspace acquisition for image blur reduction and reduced acquisition time.