Cardiac MR imaging of hemorrhagic reperfusion injury after myocardial infarction

心肌梗死后出血性再灌注损伤的心脏磁共振成像

• 批准号: 10392351
• 负责人: Walter R.T. Witschey
• 金额: $ 54.37万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10392351
• 关键词: 3-Dimensional; Acute myocardial infarction; Affect; Animals; Arrhythmia; Biocompatible Materials; Blood flow; Cardiac; Cessation of life; Clinical; Complication; Coronary; Coupled; Data; Deposition; Development; Edema; Evolution; Extracellular Matrix; Family suidae; Fibrosis; Generations; Goals; Health; Healthcare; Heart failure; Hemorrhage; High Prevalence; Histologic; Histology; Image; Imaging Techniques; Immunofluorescence Immunologic; Impairment; Implantable Defibrillators; Incidence; Infarction; Injury; Iron; Ischemia; Knowledge; Left Ventricular Function; Left Ventricular Remodeling; Magnetic Resonance Imaging; Magnetism; Maps; Measures; Medical; Methods; Modeling; Morbidity - disease rate; Myocardial; Myocardial Infarction; Myocardial Ischemia; Myocardial tissue; Myocardium; Patients; Persons; Phase; Physiologic pulse; Plasma; Predisposition; Preventive; Property; Relaxation; Reperfusion Injury; Reperfusion Therapy; Research Personnel; Risk; Severities; Signal Transduction; Specificity; Stains; Study of magnetics; Techniques; Testing; Time; Tissues; Ventricular Remodeling; Work; aggressive therapy; emission spectroscopy; experimental study; heart imaging; high risk population; imaging modality; improved; in vivo; interest; mortality; non-invasive imaging; novel; percutaneous coronary intervention; porcine model; pre-clinical; respiratory; restoration; risk stratification; stem cells; success; tool; translational goal

PROJECT SUMMARY Heart failure (HF) is an enormous health burden affecting approximately 5.1 million people in the US and is the cause of 250,000 deaths each year. Approximately 50% of HF is caused by myocardial ischemia and requires immediate restoration of coronary blood flow to the affected myocardium. However, the success of reperfusion is partly limited by intramyocardial hemorrhage, which is the deposition of intravascular material into the myocardium. Hemorrhagic reperfusion injury has high prevalence and patients have a much greater risk of adverse left ventricular remodeling, risk of fatal arrhythmia, impaired systolic function and are hospitalized at a greater rate. Recent magnetic resonance imaging techniques have improved assessment of reperfusion injury, however, the association between MRI contrasts and reperfusion injury is highly unclear, and lacks specificity to IMH. Improved imaging of IMH and accurate knowledge about its spatial and temporal evolution may be essential for delivery of optimal medical therapy in patients and critical to identify patients most at risk for adverse ventricular remodeling. The overall goal is to investigate the magnetic properties of hemorrhage and develop MRI techniques with improved specificity to hemorrhage. New MRI techniques permit noninvasive assessment of the magnetic susceptibility of tissues and can target tissue iron. Therefore, we hypothesize that MRI imaging of myocardial magnetic susceptibility can map hemorrhagic myocardium. We will perform preclinical experiments in a pig model of reperfusion injury to validate these methods, compare them with conventional MR contrasts and develop MR methods for imaging live animals.

项目摘要 心力衰竭（HF）是一种巨大的健康负担，影响美国约510万人，并且是世界上最严重的心力衰竭。 每年造成25万人死亡。大约50%的HF是由心肌缺血引起的， 立即恢复受影响心肌的冠状动脉血流。然而，再灌注的成功 部分受到心肌内出血的限制，这是血管内物质沉积到 心肌出血性再灌注损伤的患病率很高，患者的出血风险要大得多。 不利的左心室重塑，致命性心律失常的风险，收缩功能受损，并住院治疗， 更高的速率。最近的磁共振成像技术改善了再灌注损伤的评估， 然而，MRI对比度和再灌注损伤之间的关系尚不清楚，且缺乏特异性 关于IMH IMH的改进成像和关于其空间和时间演变的准确知识可能是 对于为患者提供最佳药物治疗至关重要，对于识别最有风险的患者至关重要。 不利的心室重构总体目标是研究出血的磁特性， 开发对出血具有更高特异性的MRI技术。新的MRI技术允许无创 评估组织的磁化率，并且可以靶向组织铁。因此，我们假设 MRI心肌磁化率成像可以标测出血心肌。我们将执行 在猪再灌注损伤模型中进行临床前实验以验证这些方法，将它们与 传统MR对比并开发用于活体动物成像的MR方法。

项目成果

Assessment of uterine artery geometry and hemodynamics in human pregnancy with 4d flow mri and its correlation with doppler ultrasound.

• DOI: 10.1002/jmri.26229
• 发表时间: 2019-01
• 期刊: Journal of magnetic resonance imaging : JMRI
• 作者: Hwuang E;Vidorreta M;Schwartz N;Moon BF;Kochar K;Tisdall MD;Detre JA;Witschey WRT
• 通讯作者: Witschey WRT

Hydromorphone-induced Neurostimulation in a Yorkshire Swine (Sus scrofa) after Myocardial Infarction Surgery.

约克夏猪（Sus scrofa）心肌梗塞手术后氢吗啡酮诱导的神经刺激。

• DOI: 10.30802/aalas-jaalas-18-000095
• 发表时间: 2019
• 期刊: Journal of the American Association for Laboratory Animal Science : JAALAS
• 作者: Rodriguez,Inés;Philips,BlytheH;Miedel,EmilyL;Bright,LaurenA;LaTouretteIi,PhilipC;Carty,AnthonyJ;Witschey,WalterR;Gorman,RobertC;GormanIii,JosephH;Marx,JamesO
• 通讯作者: Marx,JamesO

Endogenous T1ρ cardiovascular magnetic resonance in hypertrophic cardiomyopathy.

• DOI: 10.1186/s12968-021-00813-5
• 发表时间: 2021-10-25
• 期刊: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
• 作者: Thompson EW;Kamesh Iyer S;Solomon MP;Li Z;Zhang Q;Piechnik S;Werys K;Swago S;Moon BF;Rodgers ZB;Hall A;Kumar R;Reza N;Kim J;Jamil A;Desjardins B;Litt H;Owens A;Witschey WRT;Han Y
• 通讯作者: Han Y

Strategies for Implementing Machine Learning Algorithms in the Clinical Practice of Radiology.

在放射学临床实践中实施机器学习算法的策略。

• DOI: 10.1148/radiol.223170
• 发表时间: 2024
• 期刊: Radiology
• 影响因子: 19.7
• 作者: Chae,Allison;Yao,MichaelS;Sagreiya,Hersh;Goldberg,AriD;Chatterjee,Neil;MacLean,MatthewT;Duda,Jeffrey;Elahi,Ameena;Borthakur,Arijitt;Ritchie,MarylynD;Rader,Daniel;Kahn,CharlesE;Witschey,WalterR;Gee,JamesC
• 通讯作者: Gee,JamesC

Clinical correlates of CT imaging-derived phenotypes among lean and overweight patients with hepatic steatosis.

• DOI: 10.1038/s41598-023-49470-x
• 发表时间: 2024-01-02
• 期刊: Scientific reports
• 影响因子: 4.6