T1? IMAGING OF MYOCARDIAL INFARCTION IN HUMANS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 心肌梗死后，近四分之一的心力衰竭是由左心室重构引起的。 并认为梗塞扩大和扩张是脑梗塞的重要因素。 启动并维持这一进程。了解术后发生的病理生理学 梗塞是介入和限制梗塞扩大和脑室的必要因素。 改建。考虑到成本和可获得性的限制，表面心内膜摄影术和血清 化学检查是诊断心肌梗死和梗塞扩大的最常见方法，尽管 还使用了延迟对比增强(DCE-MRI)。该项目的目的是开发一种 KWIC重建心脏T1快速脉冲序列及1H测量 体内松弛时间。我们假设存在可测量的横向弛豫时间 在心脏周期中的变化，这可以作为心脏应激的替代测量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Post infarction, left ventricular remodeling is responsible for almost a quarter of heart failure instances and it is believed that infarct expansion and dilatation is an important factor for initiating and sustaining this process. Understanding the pathophysiology that occurs after an infarction is necessary for intervention and limiting infarct expansion and ventricular remodeling. Given cost and availability constraints, surface endocardiograms and serum chemistries are the most common methods to diagnose MI and infarct expansion, although delayed contrast enhanced (DCE-MRI) is also used. The purpose of this project is to develop a rapid pulse sequence for cardiac T1¿ imaging by KWIC reconstruction and to measure 1H relaxation times in vivo. We hypothesize that there are measurable transverse relaxation time changes during the cardiac cycle, which may be used as a surrogate measure of cardiac stress.