MOLECULAR FUNCTION OF XCT, A CONSERVED CLOCK-ASSOCIATED GENE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 我们已经克隆了一个新的基因，XCT，这是重要的时钟功能和光信号在植物中。 XCT在真核生物中高度保守，是后生动物发育所必需的，但在任何生物中都没有已知的分子功能。 我们将在裂殖酵母和植物中使用遗传和生物化学技术来确定XCT的分子作用模式。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have cloned a novel gene, XCT, which is important for clock function and light signaling in plants. XCT is highly conserved across eukaryotes, is essential for development in metazoa, but has no known molecular function in any organism. We will use genetic and biochemical techniques in fission yeast and plants to determine the molecular mode of action of XCT.