DEVELOPMENT OF AN AMPLITUDE AND FREQUENCY STABILIZED HIGH POWER OSCILLATOR

稳幅稳频大功率振荡器的研制

• 批准号: 7955976
• 负责人: PETER B. O'CONNOR
• 金额: $ 0.4万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955976
• 关键词: Amplifiers; Automobile Driving; Biology; Computer Retrieval of Information on Scientific Projects Database; Development; Frequencies; Funding; Goals; Grant; Institution; Ion Transport; Ions; Mass Spectrum Analysis; Medicine; Modification; Output; Performance; Power Sources; Research; Research Personnel; Resources; Seeds; Signal Transduction; Solutions; Source; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Staging; Testing; Transistors; United States National Institutes of Health; Work; cost; design; electric impedance; retinal rods; voltage

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In mass spectrometry, multipole ion guides are commonly driven by high voltage oscillators. Such "power supplies" usually provide sine waves in the frequency range of hundreds of KHz to a few MHz with the amplitude of less than several KV to efficiently transport ions through the multipoles. A quadrupole ion guide can be operated as a mass filter when a DC potential difference is applied to the rods of opposite polarity RF signal. High stability oscillators are required to drive quadrupole mass filters. This work (Lin et al., 2009) presents a simple, low-cost design for maintaining the output frequency and amplitude of a high power oscillator. A simple, low-cost design that incorporates a "seed" crystal to provide a stable reference frequency and an AGC circuit to stabilize the output amplitude is being tested. The goal is to achieve the frequency stability within 30 ppm and amplitude stabilization within 0.1%. To achieve this goal, the designed circuitry is divided into two parts: the signal reference source and the amplifying stage. Several different types of crystal oscillators were tested, and the impedance issues of matching the reference signal into the amplifying stage are studied. The circuit testing of the amplifying transistors is undertaking, in order to detect the proper transistors as the power amplifier to further amplifies the reference signal. In addition, the use of high power bipolar junction transistors and modification of the transformer should provide higher driving voltage, which is useful for mass filtering applications, particularly for high m/z ions generated by MALDI. The optimized solution of matching the final output signal to the quadrupole while maintaining the performance will be studied.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在质谱法中，多极离子指南通常由高压振荡器驱动。这种“电源”通常在数百kHz到几个MHz的频率范围内提供正弦波，幅度少于几个KV，以有效地通过多物传输离子。当将直流电势差应用于相反极性RF信号的杆时，四极离子指南可以作为质量过滤器操作。需要高稳定性振荡器才能驱动四极质量滤波器。这项工作（Lin等，2009）提出了一种简单的低成本设计，用于维持高功率振荡器的输出频率和振幅。 一种简单的低成本设计，结合了“种子”晶体，以提供稳定的参考频率和AGC电路以稳定输出振幅。目标是在30 ppm之内实现频率稳定性，并在0.1％以内振幅稳定。为了实现此目标，设计的电路分为两个部分：信号参考源和放大阶段。测试了几种不同类型的晶体振荡器，并研究了将参考信号匹配到放大阶段的阻抗问题。放大晶体管的电路测试正在进行，以检测适当的晶体管作为功率放大器，以进一步放大参考信号。此外，使用高功率双极连接晶体管和变压器的修饰应提供更高的驱动电压，这对于质量过滤应用非常有用，尤其是对于由Maldi产生的高M/Z离子。 将研究在保持性能的同时将最终输出信号与四极杆匹配的优化解决方案。