ABERRANT BRAIN ACTIVATION DURING GAZE PROCESSING IN MALES WITH FRAGILE X

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 导言： 眼神交流是人类社会行为的基本组成部分。患有脆性X综合征的人，特别是男性，会避免眼神接触，并表现出其他社交缺陷。到目前为止，脆性X综合征的这种行为只在表现出较少程度的凝视厌恶的女性中进行了研究。 具体目标： 目的：应用功能磁共振成像技术确定脆性X综合征青少年男性患者直视知觉的神经相关因素。 方法： 研究对象：13名患有脆性X综合征的青春期男性，10名发育迟缓的男性和13名正常发育的对照组 主要观察指标：功能磁共振成像中的行为表现和脑激活在呈现眼睛指向或避开受试者的面孔时进行评估。进行了与任务绩效相关的全脑和凝视相关感兴趣区分析和回归分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Eye contact is a fundamental component of human social behavior. Individuals with fragile X syndrome, particularly males, avoid eye contact and display other social deficits. To date, this behavior in fragile X syndrome has only been studied in females who show lesser degrees of gaze aversion. Specific Aims: To determine the neural correlates of the perception of direct eye gaze in adolescent males with fragile X syndrome using functional magnetic resonance imaging. Methods: Participants: 13 adolescent males with fragile X syndrome, 10 developmentally-delayed and 13 typically-developing controls Main Outcome Measures: Behavioral performance and brain activation during functional magnetic resonance imaging were evaluated during the presentation of faces with eye-gaze directed to or averted away from subjects. Whole-brain and gaze-related regions-of-interest analyses and regression analyses with task performance were performed.