ABERRANT BRAIN ACTIVATION DURING GAZE PROCESSING IN MALES WITH FRAGILE X

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 中心，但不一定是研究者所在的机构。 简介： 眼神交流是人类社会行为的基本组成部分。患有脆性X综合征的人，特别是男性，避免目光接触，并表现出其他社交缺陷。 迄今为止，脆性X综合征的这种行为仅在表现出较低程度的凝视厌恶的女性中进行了研究。 具体目标： 利用功能性磁共振成像确定脆性X综合征青少年男性直接注视知觉的神经相关性。 研究方法： 参与者：13名患有脆性X综合征的青少年男性，10名发育迟缓和13名典型发育对照 主要结局指标：在功能磁共振成像过程中的行为表现和大脑激活进行了评估，在介绍的面孔与眼睛凝视直接或避免远离受试者。 全脑和凝视相关区域的兴趣分析和回归分析与任务性能进行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Eye contact is a fundamental component of human social behavior. Individuals with fragile X syndrome, particularly males, avoid eye contact and display other social deficits. To date, this behavior in fragile X syndrome has only been studied in females who show lesser degrees of gaze aversion. Specific Aims: To determine the neural correlates of the perception of direct eye gaze in adolescent males with fragile X syndrome using functional magnetic resonance imaging. Methods: Participants: 13 adolescent males with fragile X syndrome, 10 developmentally-delayed and 13 typically-developing controls Main Outcome Measures: Behavioral performance and brain activation during functional magnetic resonance imaging were evaluated during the presentation of faces with eye-gaze directed to or averted away from subjects. Whole-brain and gaze-related regions-of-interest analyses and regression analyses with task performance were performed.