Sequencing and the molecular dissection of a 'fitness' locus in Soay sheep

索伊羊“健康”基因座的测序和分子解剖

• 批准号: NE/F001371/1
• 负责人: J Slate
• 金额: $ 3.99万
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FF001371%2F1
• 关键词: Sequencing; molecular; dissection; fitness; locus

This proposal will exploit recent discoveries made under NERC EG project 'QTL mapping in natural populations using linkage and linkage disequilibrium' to address a major question in evolutionary genetics: are negative genetic correlations due to pleiotropy at a single locus, or linkage disequilibrium between closely linked loci? We have identified a negative genetic correlation for fitness in the vicinity of the TYRP1 gene underlying a coat colour polymorphism in Soay sheep. We propose to characterise sequence diversity and patterns of linkage disequilibrium in an ~600 Kbp region flanking TYRP1 in order to dissect the molecular basis of the genetic correlation.

该提案将利用 NERC EG 项目“使用连锁和连锁不平衡在自然群体中进行 QTL 作图”的最新发现来解决进化遗传学中的一个主要问题：负遗传相关是由于单个基因座的多效性还是由于紧密连锁的基因座之间的连锁不平衡？我们已经确定了索伊羊毛色多态性背后的 TYRP1 基因附近的适应性负遗传相关性。我们建议表征 TYRP1 侧翼约 600 Kbp 区域的序列多样性和连锁不平衡模式，以剖析遗传相关性的分子基础。