LOCAL STRUCTURE OF WATER ACROSS THE PHASE DIAGRAM, IN AQUEOUS AND IN BIOLOGICAL

水体和生物体中水在相图中的局部结构

• 批准号: 7954265
• 负责人: ANDERS NILSSON
• 金额: $ 0.02万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7954265
• 关键词: Address; Anions; Biological; Cations; Chemicals; Computer Retrieval of Information on Scientific Projects Database; Data; Data Set; Funding; Furuncles; Grant; Institution; Measures; Micelles; Mono-S; Phase; Raman Spectrum Analysis; Research; Research Personnel; Resources; Roentgen Rays; Solutions; Source; Structure; Techniques; Temperature; Thermodynamics; United States National Institutes of Health; Water; aqueous; biological systems; improved; pressure; programs; simulation; structural biology; synchrotron radiation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose a research program at SSRL on water across the phase diagram and in different chemical surroundings using X-ray Raman Spectroscopy (XRS) in combination with theoretical simulations to gain new unique information on the local structure of water. We plan to measure XRS spectra at a number of different temperatures from the supercooled region (-20¿C) to well above the boiling point (200¿C) and pressures up to 400 MPa. Furthermore, we will investigate a number of aqueous solutions at various concentrations with different mono-, di- and trivalent cations and different monovalent anions. The structure of water in biological systems will also be addressed in, e.g., reverse micelles. This extensive dataset of local water structure is needed for a firm theoretical analysis and for comparing the results with the existing data using other techniques, in order to get an improved and detailed understanding of the local structure of water and how it varies with thermodynamic and chemical conditions.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们在 SSRL 提出了一项关于水在相图和不同化学环境中的研究计划，利用 X 射线拉曼光谱 (XRS) 与理论模拟相结合，以获得有关水局部结构的新的独特信息。我们计划在从过冷区域 (-20°C) 到远高于沸点 (200°C) 的多种不同温度和高达 400 MPa 的压力下测量 XRS 光谱。此外，我们将研究具有不同一价、二价和三价阳离子以及不同一价阴离子的不同浓度的多种水溶液。生物系统中水的结构也将在反胶束等方面得到解决。需要这种广泛的局部水结构数据集来进行可靠的理论分析，并将结果与​​使用其他技术的现有数据进行比较，以便更好地、详细地了解水的局部结构以及它如何随热力学和化学条件变化。