STRUCTURAL GENOMICS FOR DIFFICULT TARGETS AND/OR DISEASE-RELATED PROTEINS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 结构基因组学已经进入了一个新的时代，其重点已经转移到为生物界做出更实质性的贡献。 我们组操作两个PSI-II中心的X射线晶体学设备？结构和功能创新综合中心（ISFI）和结核病结构基因组学联盟（TBSGC）。 这两个中心的重点是开发技术，以解决重要但困难的目标（ISFI）的晶体结构，并解决结核分枝杆菌的重要药物靶点。 由于目标的难度，大多数晶体很难获得，而且往往非常小。 为蛋白质晶体学优化的良好管理和强烈的同步辐射源通常是进行有效衍射实验的唯一希望。 表征和解决这些具有生物医学重要性的蛋白质的晶体结构将对生物界产生重大影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Structural genomics has reached an era where focus has been shifted to making more substantial contribution to the biological community. Our group operates the x-ray crystallography facility of two PSI-II centers ? the Integrated Center for Structure and Function Innovation (ISFI) and the TB Structural Genomics Consortium (TBSGC). The two centers focus on develop technologies to solve crystal structures of important but difficult targets (ISFI), and to solve those of important drug targets of Mycobacterium tuberculosis. Because of the difficulty of the targets, most of the crystals are difficult to obtain and often very small. Well managed and intense synchrotron sources optimized for protein crystallography are usually the only hope in conducting effective diffraction experiments. Characterizing and solving the crystal structures of these proteins of biomedical importance will bring substantial impact to the biological community.