STRUCTURAL GENOMICS FOR DIFFICULT TARGETS AND/OR DISEASE-RELATED PROTEINS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 结构基因组学已经到了一个重点已经转移到为生物界做出更实质性贡献的时代。我们集团运营着两个PSI-II中心的X射线结晶学设施？结构和功能创新综合中心(ISFI)和结核病结构基因组学联盟(TBSGC)。这两个中心专注于开发技术来解决重要但困难的靶标(ISFI)的晶体结构，以及解决结核分枝杆菌的重要药物靶标的晶体结构。由于靶材的难度，大多数晶体都很难获得，而且往往很小。为蛋白质结晶学优化的管理良好和高强度的同步加速器源通常是进行有效的衍射实验的唯一希望。表征和解决这些具有生物医学意义的蛋白质的晶体结构将给生物界带来实质性的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Structural genomics has reached an era where focus has been shifted to making more substantial contribution to the biological community. Our group operates the x-ray crystallography facility of two PSI-II centers ? the Integrated Center for Structure and Function Innovation (ISFI) and the TB Structural Genomics Consortium (TBSGC). The two centers focus on develop technologies to solve crystal structures of important but difficult targets (ISFI), and to solve those of important drug targets of Mycobacterium tuberculosis. Because of the difficulty of the targets, most of the crystals are difficult to obtain and often very small. Well managed and intense synchrotron sources optimized for protein crystallography are usually the only hope in conducting effective diffraction experiments. Characterizing and solving the crystal structures of these proteins of biomedical importance will bring substantial impact to the biological community.