X-RAY SPECTROSCOPY OF IRON FROM MOON DUST SIMULANTS INCORPORATED INTO LIVING TIS

将月球尘埃模拟物中的铁 X 射线光谱纳入生活 TIS

• 批准号: 7954434
• 负责人: Oana Marcu
• 金额: $ 0.02万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7954434
• 关键词: Adhesives; Affect; Astronauts; Biosensor; Computer Retrieval of Information on Scientific Projects Database; Deposition; Drosophila genus; Dust; Fluorescence Spectroscopy; Funding; Future; Genes; Goals; Grant; Health; Human; Huntington Disease; In Situ; Institution; Iron; Life; Life Support Systems; Maps; Measures; Mission; Moon; Neurodegenerative Disorders; Property; Research; Research Personnel; Resources; Roentgen Rays; Science; Source; Space Explorations; Space Suits; Specimen; Surface; Testing; Tissues; Toxic effect; United States National Institutes of Health; X ray spectroscopy; hazard; in vivo; insight; programs; sensor; structural biology; synchrotron radiation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Lunar dust has raised issues for space exploration ever since the Apollo missions. Its unique adhesive and abrasive properties make it a hazard for space suits materials, life support systems and astronaut health. With NASA?s program for returning to the Moon, the concerns for the lunar dust as a factor affecting human exploration of the Moon have become pressing. Lunar dust contains iron with toxic potential. The fruit fly Drosophila can be used as a biological sensor to measure the iron toxicity of lunar dust. Fruit flies carrying the human gene responsible for the Huntington?s neurodegenerative disease are sensitive indicators of the toxicity of iron. Synchrotron radiation is uniquely suitable for refined elemental analysis of small living specimens. X-ray fluorescence spectroscopy can be used to localize the deposition of iron into fruit fly tissues and to obtain spectra to speciate iron in situ. The long-term goal is to develop the fruit fly as a sensor the toxicity of lunar dust to be available for a science payload on a future lunar mission. This would allow measuring the toxicity of lunar dust in vivo on the surface of the Moon and test countermeasures to mitigate its toxic effects. The objective of this project is to provide fundamental insight into the geochemical properties and toxicity of lunar dust by using x-ray fluorescence spectroscopy and elemental mapping to determine the incorporation of iron from lunar dust into living tissues.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 自阿波罗任务以来，月球尘埃就给太空探索带来了问题。其独特的粘合和研磨特性使其对宇航服材料、生命支持系统和宇航员的健康构成危害。随着美国宇航局重返月球计划的实施，对月球尘埃作为影响人类探索月球的因素的担忧变得越来越紧迫。月球尘埃中含有具有潜在毒性的铁。果蝇可用作生物传感器来测量月球尘埃的铁毒性。携带导致亨廷顿神经退行性疾病的人类基因的果蝇是铁毒性的敏感指标。同步辐射特别适合小型活体样本的精细元素分析。 X 射线荧光光谱可用于定位铁在果蝇组织中的沉积，并获得原位铁形态的光谱。长期目标是开发果蝇作为月球尘埃毒性传感器，用于未来月球任务的科学有效载荷。这将允许测量月球表面月球尘埃体内的毒性，并测试减轻其毒性影响的对策。该项目的目标是通过使用 X 射线荧光光谱和元素测绘来确定月球尘埃中铁与活体组织的结合情况，从而对月球尘埃的地球化学性质和毒性提供基本的了解。