X-RAY SPECTROSCOPY OF IRON FROM MOON DUST SIMULANTS INCORPORATED INTO LIVING TIS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 自从阿波罗任务以来，月球尘埃就给太空探索带来了问题。其独特的粘合和研磨性能使其对宇航服材料，生命支持系统和宇航员健康构成危害。与NASA？随着美国重返月球计划的实施，人们对月球尘埃作为影响人类月球探测的一个因素的关注变得越来越紧迫。月球尘埃含有潜在有毒的铁。果蝇可以作为生物传感器来测量月球尘埃的铁毒性。果蝇携带人类基因负责亨廷顿？神经退行性疾病是铁毒性的敏感指标。同步辐射是唯一适用于精细元素分析的小活标本。X射线荧光光谱法可用于定位铁沉积到果蝇组织中，并获得光谱以原位形成铁。长期目标是将果蝇作为一种传感器，用于探测月球尘埃的毒性，以便在未来的月球使命中用于科学有效载荷。这将允许在月球表面活体测量月球尘埃的毒性，并测试减轻其毒性影响的对策。该项目的目标是通过使用X射线荧光光谱法和元素绘图来确定月球尘埃中的铁与活组织的结合，从而对月球尘埃的地球化学特性和毒性提供基本的了解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Lunar dust has raised issues for space exploration ever since the Apollo missions. Its unique adhesive and abrasive properties make it a hazard for space suits materials, life support systems and astronaut health. With NASA?s program for returning to the Moon, the concerns for the lunar dust as a factor affecting human exploration of the Moon have become pressing. Lunar dust contains iron with toxic potential. The fruit fly Drosophila can be used as a biological sensor to measure the iron toxicity of lunar dust. Fruit flies carrying the human gene responsible for the Huntington?s neurodegenerative disease are sensitive indicators of the toxicity of iron. Synchrotron radiation is uniquely suitable for refined elemental analysis of small living specimens. X-ray fluorescence spectroscopy can be used to localize the deposition of iron into fruit fly tissues and to obtain spectra to speciate iron in situ. The long-term goal is to develop the fruit fly as a sensor the toxicity of lunar dust to be available for a science payload on a future lunar mission. This would allow measuring the toxicity of lunar dust in vivo on the surface of the Moon and test countermeasures to mitigate its toxic effects. The objective of this project is to provide fundamental insight into the geochemical properties and toxicity of lunar dust by using x-ray fluorescence spectroscopy and elemental mapping to determine the incorporation of iron from lunar dust into living tissues.