SIMULATION OF ARTERIAL BLOOD FLOW DYNAMICS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 我们想用计算流体力学的方法来研究红细胞压积在动脉疾病发生中的作用。目前流行病学和临床研究表明，红细胞压积水平是动脉疾病发生的一个因素。然而，这些发现缺乏基本解释的支持。我们使用Navier Stock方程和各种血液流变学模型来描述血流动力学，并分析血流行为如何影响动脉疾病的发生。本研究的发现为动脉疾病的早期临床和流行病学发现提供了理论解释，动脉疾病是世界上已知的主要死亡原因之一。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We would like to investigate the role of hematocrit in the genesis of arterial diseases using computational fluid dynamics approach. Current epidemiological and clinical studies show hematocrit level as one factor contributing to the genesis of arterial diseases. However, such findings lacks support of fundamental explanation. We use Navier Stock's equation and various blood rheology models to depict the flow dynamics and make analysis on how the flow behavior affects the onset of arterial diseases. Findings in this study provides theoretical explanation to earlier clinical and epidemiological findings to arterial diseases which are known to be one of the principal cause of death in the world.