SIMULATION OF MACROMOLECULAR TRANSPORT IN THE WALL OF BRANCHED ARTERIES

分支动脉壁中大分子运输的模拟

• 批准号: 7601263
• 负责人: SHEWAFERAW SOLOMAN SHIBESHI
• 金额: $ 0.03万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601263
• 关键词: Arteries; Atherosclerosis; Blood flow; Computer Retrieval of Information on Scientific Projects Database; Computer software; Condition; Diffusion; Equation; Equilibrium; Funding; Grant; Institution; Lipoproteins; Low-Density Lipoproteins; Methods; Modeling; Plasma; Process; Research; Research Personnel; Resources; Serum Albumin; Site; Solutions; Source; Trees; United States National Institutes of Health; abstracting; macromolecule; mathematical model; shear stress; simulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Keywords: transport, serum albumin, lipoprotein, macromolecules Abstract: Arterial blood flow dynamics and transport of atherogenic plasma components such as low-density lipoprotein (LDL) influence the genesis of athereosclerosis. Flow disturbances and the associated alteration of wall shear stress at branches and curvatures of the arterial tree are phenomenon known to control atherosclerosis. Elevated local mass transfer of atherogenic plasma components at those sites is also an additional factor which causes the build of plaque. In this study simulation of aterial blood flow dynamics and transport of atherogenic components in a three dimensional T-junction under transient flow conditions is carried out. The generalized momentum balance equation to model the blood flow and the advective-diffusion equation to model the mass transfer are used in the mathematical model. In the solution process Computational Flow Dynamics (CFD) Software FLUENT 6.1 will be used to implement the Finite volume method.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 关键词： 运输、血清白蛋白、脂蛋白、大分子 抽象的： 动脉血流动力学和致动脉粥样硬化血浆成分（例如低密度脂蛋白（LDL））的运输影响动脉粥样硬化的发生。血流扰动以及动脉树分支和曲率处壁剪切应力的相关改变是已知控制动脉粥样硬化的现象。这些部位致动脉粥样硬化血浆成分的局部质量转移升高也是导致斑块形成的另一个因素。在这项研究中，模拟了瞬时流动条件下动脉血流动力学和三维 T 形接头中致动脉粥样硬化成分的运输。数学模型中使用广义动量平衡方程来模拟血流，并使用平流扩散方程来模拟质量传递。在求解过程中，将使用计算流动动力学（CFD）软件FLUENT 6.1来实现有限体积法。