SIMULATION OF MACROMOLECULAR TRANSPORT IN THE WALL OF BRANCHED ARTERIES

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Keywords: transport, serum albumin, lipoprotein, macromolecules Abstract: Arterial blood flow dynamics and transport of atherogenic plasma components such as low-density lipoprotein (LDL) influence the genesis of athereosclerosis. Flow disturbances and the associated alteration of wall shear stress at branches and curvatures of the arterial tree are phenomenon known to control atherosclerosis. Elevated local mass transfer of atherogenic plasma components at those sites is also an additional factor which causes the build of plaque. In this study simulation of aterial blood flow dynamics and transport of atherogenic components in a three dimensional T-junction under transient flow conditions is carried out. The generalized momentum balance equation to model the blood flow and the advective-diffusion equation to model the mass transfer are used in the mathematical model. In the solution process Computational Flow Dynamics (CFD) Software FLUENT 6.1 will be used to implement the Finite volume method.