SIMULATION OF ARTERIAL BLOOD FLOW DYNAMICS

动脉血流动力学模拟

• 批准号: 8171781
• 负责人: SHEWAFERAW SOLOMAN SHIBESHI
• 金额: $ 0.11万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171781
• 关键词: Behavior; Biological Process; Blood; Blood flow; Carotid Arteries; Computer Retrieval of Information on Scientific Projects Database; Data; Disease; Disease Progression; Educational process of instructing; Environment; Equation; Funding; Gel; Grant; Human; Imagery; Institution; Liquid substance; Methods; Modeling; Nature; Physiological; Physiology; Procedures; Process; Research; Research Personnel; Resources; Rest; Software Tools; Solid; Solutions; Source; Stress; Supercomputing; United States National Institutes of Health; X-Ray Computed Tomography; bioimaging; blood rheology; design; human subject; interest; mathematical model; novel diagnostics; repository; simulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We would like to investigate the yield stress behavior of blood. Particular interest is modulation of flow dynamics and arterial disease progressions due to yield stress levels. Blood is a yield stress fluid. It is a solid like gel when it is at rest and when it is sheared it starts to flow and behave like a Casson fluid. Blood rheology analysis allows us to describe several biological processes which are essential to understand human physiology and disease processes and also to design novel diagnostic and treatment procedures. Blood rheology will be represented as a Casson fluid with different degrees of Casson yield stress designating various physiological conditions. We use the Navier-Stokes equation to model arterial blood flow dynamics. The three-dimensional CT scan imagery of carotid arteries of a human subject to be used will be obtained from research and teaching biomedical image repository. The mathematical models to be used in the study are non-linear and transit in their nature and are not amenable to analytic solution, and a numerical method, finite volume method, is implemented. The numerical approach is computational intensive; as a result, the simulation will be conducted in supercomputing environment. Computational fluid dynamics software tools such us FLUENT and GAMBIT which are available at Pittsburgh Super Computing Center (PSC) will be used in simulation and visualization of data.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们想要研究血液的屈服应力行为。特别令人感兴趣的是由于屈服应力水平对血流动力学和动脉疾病进展的调节。血液是一种屈服应力流体。当它静止时，它是一种固体状的凝胶，当它被剪切时，它开始流动，行为像卡森流体。血液流变学分析使我们能够描述几个生物过程，这些过程对于理解人类生理和疾病过程以及设计新的诊断和治疗程序是必不可少的。血液流变学将被表示为卡松流体，具有不同程度的卡松屈服应力，表示不同的生理条件。我们使用Navier-Stokes方程来模拟动脉血流动力学。将要使用的人体颈动脉的三维CT扫描图像将从研究和教学生物医学图像库中获得。研究中使用的数学模型本质上是非线性和过渡性的，不能进行解析解，并实现了一种数值方法--有限体积法。数值方法是计算密集型的，因此模拟将在超级计算环境中进行。匹兹堡超级计算中心(PSC)提供的计算流体力学软件工具，如USFLUENT和GAMBIT，将用于数据的模拟和可视化。