STRUCTURAL STUDIES OF THE RNA INTERFERENCE MACHINERY
STRUCTURAL STUDIES OF THE RNA INTERFERENCE MACHINERY
批准号:
7956452
负责人:
IAN JOHN MACRAE
金额:
$2.19万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-05-01 至 2010-04-30
关键词:
Computer Retrieval of Information on Scientific Projects DatabaseFamilyFundingGene SilencingGoalsGrantHumanInstitutionMicroRNAsMicroscopyMolecularMolecular StructurePathway interactionsRNA InterferenceRNA-Induced Silencing ComplexRegulationResearchResearch PersonnelResourcesSourceUnited States National Institutes of HealthWorkprotein complex
中文摘要
点击翻译按钮获取中文摘要
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
RNA interference (RNAi) is a conserved mechanism of eukaryotic gene silencing and regulation. In humans RNAi and the related micro-RNA pathways are carried out by a family of large, related protein complexes, generically termed RNA induced silencing complexes (RISCs). The goal of this work is to determine molecular structures of the various forms of RISC in an effort to better understand the mechanism of gene silencing by RNAi.
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Mouse models for decoding microRNA regulation in diverse tissues and cell types
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批准号:10194631
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项目类别:
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资助金额:$22.19万
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财政年份:2021
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负责人:IAN JOHN MACRAE
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依托单位:
Mouse models for decoding microRNA regulation in diverse tissues and cell types
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批准号:10043075
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项目类别:
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资助金额:$26.63万
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财政年份:2020
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负责人:IAN JOHN MACRAE
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依托单位:
Structural and Mechanistic basis for RNA Silencing
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批准号:9979882
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项目类别:
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资助金额:$67.73万
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财政年份:2018
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负责人:IAN JOHN MACRAE
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依托单位:
Structural and Mechanistic basis for RNA Silencing
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批准号:10448453
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项目类别:
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资助金额:$67.73万
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财政年份:2018
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负责人:IAN JOHN MACRAE
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依托单位:
Structural and Mechanistic basis for RNA Silencing
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批准号:10213093
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项目类别:
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资助金额:$67.73万
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财政年份:2018
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负责人:IAN JOHN MACRAE
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依托单位:
Structural and Mechanistic basis for RNA Silencing
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批准号:10623935
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项目类别:
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资助金额:$68.1万
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财政年份:2018
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负责人:IAN JOHN MACRAE
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依托单位:
Structure and Mechanism of the RISC-loading Complex
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批准号:9133428
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项目类别:
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资助金额:$38.02万
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财政年份:2015
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负责人:IAN JOHN MACRAE
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依托单位:
Methods for controlling small RNA stability
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批准号:9022315
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项目类别:
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资助金额:$25.12万
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财政年份:2015
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负责人:IAN JOHN MACRAE
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依托单位:
Structure and Mechanism of the RISC-loading Complex
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批准号:9314277
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项目类别:
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资助金额:$38.02万
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财政年份:2015
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负责人:IAN JOHN MACRAE
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依托单位:
Structural Basis for RNA Silencing by Human Argonaute2
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批准号:8708908
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项目类别:
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资助金额:$36.01万
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财政年份:2013
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负责人:IAN JOHN MACRAE
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依托单位:
Structural Basis for RNA Silencing by Human Argonaute2
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批准号:8852646
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项目类别:
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资助金额:$36.01万
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财政年份:2013
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负责人:IAN JOHN MACRAE
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依托单位:
Structural Basis for RNA Silencing by Human Argonaute2
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批准号:8579676
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项目类别:
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资助金额:$36.01万
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财政年份:2013
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负责人:IAN JOHN MACRAE
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依托单位:
3D STRUCTURE OF THE HUMAN RISC-LOADING COMPLEX
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批准号:8362257
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项目类别:
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资助金额:$0.03万
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财政年份:2011
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负责人:IAN JOHN MACRAE
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依托单位:
STRUCTURAL STUDIES OF THE RNA INTERFERENCE MACHINERY
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批准号:8362459
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项目类别:
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资助金额:$3.86万
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财政年份:2011
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负责人:IAN JOHN MACRAE
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依托单位:
STRUCTURAL STUDIES OF THE RNA INTERFERENCE MACHINERY
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批准号:8169680
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项目类别:
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资助金额:$2.2万
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财政年份:2010
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负责人:IAN JOHN MACRAE
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依托单位:
3D STRUCTURE OF THE HUMAN RISC-LOADING COMPLEX
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批准号:8170240
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项目类别:
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资助金额:$0.03万
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财政年份:2010
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负责人:IAN JOHN MACRAE
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依托单位:
Structure and Mechanism of the RISC-loading Complex
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批准号:7931265
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项目类别:
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资助金额:$5.03万
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财政年份:2009
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负责人:IAN JOHN MACRAE
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依托单位:
Structure and Mechanism of the RISC-loading Complex
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批准号:7996046
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项目类别:
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资助金额:$34.34万
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财政年份:2008
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负责人:IAN JOHN MACRAE
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依托单位:
Structure and Mechanism of the RISC-loading Complex
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批准号:8204417
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项目类别:
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资助金额:$34.34万
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财政年份:2008
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负责人:IAN JOHN MACRAE
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依托单位:
STRUCTURAL STUDIES OF THE RNA INTERFERENCE MACHINERY
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批准号:7723585
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项目类别:
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资助金额:$1.26万
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财政年份:2008
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负责人:IAN JOHN MACRAE
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依托单位:
国内基金
海外基金
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批准号:31671271
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项目类别:面上项目
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资助金额:62.0万元
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批准年份:2016
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负责人:李建雄
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依托单位:
del Pezzo曲面的family上的E_n向量丛
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批准号:11501201
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项目类别:青年科学基金项目
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资助金额:18.0万元
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批准年份:2015
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负责人:陈云霞
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依托单位:
Pim family调控白血病细胞和造血微环境之间Cross Talk在急性髓系白血病中的作用
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批准号:81100330
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项目类别:青年科学基金项目
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资助金额:24.0万元
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批准年份:2011
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负责人:吴俣
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依托单位: