STRUCTURAL STUDIES OF THE RNA INTERFERENCE MACHINERY

RNA干扰机制的结构研究

• 批准号: 8362459
• 负责人: IAN JOHN MACRAE
• 金额: $ 3.86万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362459
• 关键词: Family; Funding; Gene Expression Regulation; Gene Silencing; Goals; Grant; Human; MicroRNAs; Microscopy; Molecular; Molecular Structure; National Center for Research Resources; Pathway interactions; Principal Investigator; RNA Interference; RNA-Induced Silencing Complex; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; Work; cost; protein complex

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. RNA interference (RNAi) is a conserved mechanism of eukaryotic gene silencing and regulation. In humans RNAi and the related micro-RNA pathways are carried out by a family of large, related protein complexes, generically termed RNA induced silencing complexes (RISCs). The goal of this work is to determine molecular structures of the various forms of RISC in an effort to better understand the mechanism of gene silencing by RNAi.

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