STRUCTURE OF THE KIT RECEPTOR TYROSINE KINASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 受体酪氨酸激酶(RTK)是一种大的单跨膜蛋白，介导许多重要的细胞功能。虽然在了解受体的可溶性域方面已经取得了很大的进展，但整个受体的图像，包括跨越螺旋的膜。这种信息的缺乏限制了对这类重要的膜蛋白的信号转导机制(S)的全面机械理解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Receptor Tyrosine Kinases (RTKs) are large single span membrane proteins that mediate many important cellular functions. While much progress has been made in the understanding of the soluble domains of the receptors, a picture of the whole receptor, including the membrane spanning helix. This lack in information is limiting for a full mechanstic understanding of the signal transduction mechanism(s) of this important class of membrane proteins.