STRUCTURE OF THE KIT RECEPTOR TYROSINE KINASE

试剂盒受体酪氨酸激酶的结构

• 批准号: 7956464
• 负责人: VINZENZ UNGER
• 金额: $ 1.29万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7956464
• 关键词: Cell physiology; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Institution; Mediating; Membrane; Membrane Proteins; Microscopy; Molecular; Receptor Protein-Tyrosine Kinases; Research; Research Personnel; Resources; Signal Transduction; Source; Structure; United States National Institutes of Health; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Receptor Tyrosine Kinases (RTKs) are large single span membrane proteins that mediate many important cellular functions. While much progress has been made in the understanding of the soluble domains of the receptors, a picture of the whole receptor, including the membrane spanning helix. This lack in information is limiting for a full mechanstic understanding of the signal transduction mechanism(s) of this important class of membrane proteins.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 受体酪氨酸激酶（RTK）是介导许多重要细胞功能的大型单跨膜蛋白。尽管在理解受体的可溶域中取得了很多进展，但整个受体的图片，包括跨螺旋的膜。这种缺乏信息限制了对这种重要类型膜蛋白的信号转导机制的全面理解。