STRUCTURE OF THE KIT RECEPTOR TYROSINE KINASE

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 受体酪氨酸激酶（RTK）是介导许多重要细胞功能的大的单跨膜蛋白。虽然在对受体的可溶性结构域的理解方面已经取得了很大进展，但整个受体的图片，包括跨膜螺旋。这种信息的缺乏限制了对这类重要膜蛋白的信号转导机制的全面机械理解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Receptor Tyrosine Kinases (RTKs) are large single span membrane proteins that mediate many important cellular functions. While much progress has been made in the understanding of the soluble domains of the receptors, a picture of the whole receptor, including the membrane spanning helix. This lack in information is limiting for a full mechanstic understanding of the signal transduction mechanism(s) of this important class of membrane proteins.