STRUCTURE OF THE KIT RECEPTOR TYROSINE KINASE

试剂盒受体酪氨酸激酶的结构

• 批准号: 8169690
• 负责人: VINZENZ UNGER
• 金额: $ 1.29万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169690
• 关键词: Cell physiology; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Institution; Mediating; Membrane; Membrane Proteins; Receptor Protein-Tyrosine Kinases; Research; Research Personnel; Resources; Signal Transduction; Source; Structure; United States National Institutes of Health; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Receptor Tyrosine Kinases (RTKs) are large single span membrane proteins that mediate many important cellular functions. While much progress has been made in the understanding of the soluble domains of the receptors, a picture of the whole receptor, including the membrane spanning helix. This lack in information is limiting for a full mechanstic understanding of the signal transduction mechanism(s) of this important class of membrane proteins.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 受体酪氨酸激酶 (RTK) 是大型单跨膜蛋白，可介导许多重要的细胞功能。虽然在理解受体可溶性结构域方面已经取得了很大进展，但整个受体的图片，包括跨膜螺旋。这种信息的缺乏限制了对这一类重要膜蛋白的信号转导机制的全面理解。