PERLECAN AND HEPARANASE IN CARTILAGE GROWTH AND HEALING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在第一个项目中，Farach-Carson博士建议精确定义Perlecan(PLN)及其相关的硫酸乙酰肝素(HS)蛋白聚糖链在软骨生物学中所扮演的结构和功能角色。HS蛋白多糖最近已成为软骨生物学的关键调节因子，在胚胎发育、成人机体软骨结构的维持以及因年龄、骨关节炎或损伤而导致的软骨损伤的再生中发挥关键作用。Farach-Carson博士等人使用了体外软骨形成模型和携带PLN或HS生物合成酶突变的小鼠的组合。将提出的假设是，PLN和乙酰肝素酶I在正常的软骨形成和软骨愈合过程中是必不可少的参与者，并且它们在这些过程中的复杂角色与不同域中加密的特殊功能相关联，并且需要HS的存在和周转。法拉赫-卡森博士是一名全职教授，不会有导师。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In the first project, Dr. Farach-Carson proposes to define precisely the structural and functional roles that perlecan (Pln) and its associated heparan sulfate (HS) proteoglycan chains play in cartilage biology. HS proteoglycans have recently emerged as key regulators of cartilage biology and play critical roles during embryonic development, in maintenance of cartilage structures in the adult organism, and in regrowth of damaged cartilage resulting from age, osteoarthritis or injury. Using a combination of in vitro chondrogenesis models and mice harboring mutations in Pln or HS biosynthetic enzymes, Dr. Farach-Carson et al. will address the hypothesis that Pln and heparanase I are essential players in normal chondrogenesis and cartilage healing, and that their complex roles in these processes are associated with specialized functions encrypted within the various domains and require the presence and turnover of HS. Dr. Farach-Carson is a full professor and will not have a mentor.