PROTEIN STRUCTURE-FUNCTION IN GASTRIC MICROBIAL PATHOGENESIS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目研究了独特微生物对酸性环境的耐受性，例如在胃中发现的酸性环境。这些微生物的耐酸性反应（ATR）似乎涉及一系列事件，包括并超过了常见病原体中通常看到的事件。除了正常预期的应激反应外，代谢途径似乎也发生了显著变化

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project investigates the tolerance of unique microbes to acidic environments such as that found in the stomach. The acid tolerance response (ATR) of these microbes appears to involve a sequence of events that both includes and surpasses that which is normally seen in common pathogens. In addition to the normally expected stress response, there appears to be a significant change in metabolic pathways