BACTERIAL ANTIBIOTIC RESISTANCE IN AGRICULTURE

农业中的细菌抗生素耐药性

• 批准号: 7960222
• 负责人: MANUEL F VARELA
• 金额: $ 9.65万
• 依托单位: NEW MEXICO STATE UNIVERSITY LAS CRUCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960222
• 关键词: Agriculture; Antimicrobial Resistance; Antimicrobial susceptibility; Bacteria; Bacterial Antibiotic Resistance; Biomedical Research; Clinical; Computer Retrieval of Information on Scientific Projects Database; Data; Disease Outbreaks; Enterobacteriaceae; Family; Fostering; Funding; Gram-Negative Bacteria; Grant; Incidence; Institution; New Mexico; Research; Research Personnel; Resistance; Resources; Salmonella enterica; Salmonella infections; Source; Testing; Texas; United States; United States National Institutes of Health; antimicrobial drug; clinical efficacy; clinically relevant; member; prevent; resistance mechanism; retinal rods

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The bacterium Salmonella enterica is a clinically-important facultatively anaerobic rod and a member of the Enterobacteriaceae family of Gram-negative bacteria. Recently, an outbreak of salmonellosis occurred in the United States. New Mexico and Texas had relatively higher incidence rates of salmonellosis than most other states. In order to reestablish clinical efficacy, it would be important to determine the extent to which specific antimicrobial agents are effective against S. enterica which are implicated in outbreaks. Hence, we will test the hypothesis that the NM clinical isolates of S. enterica are susceptible to clinically-relevant antimicrobial agents. Such antimicrobial susceptibility data is necessary for ultimately circumventing resistance determinants and in establishing practices which prevent conditions that foster emergence of antimicrobial resistance mechanisms.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 肠道沙门氏菌（Salmonella enterica）是临床上重要的兼性厌氧杆菌，是革兰氏阴性菌的肠杆菌科（Enterobacteriaceae）的成员。 最近，美国爆发了沙门氏菌病。 新墨西哥州和得克萨斯州的沙门氏菌病发病率相对高于其他大多数州。为了重建临床疗效，确定特异性抗菌药物对沙门氏菌的有效程度将是重要的。与疾病爆发有关的肠道病毒。 因此，我们将检验以下假设：S.肠杆菌对临床相关的抗微生物剂敏感。 这些抗菌药物敏感性数据对于最终规避耐药决定因素和建立预防促进抗菌药物耐药机制出现的条件的实践是必要的。