Cytogenetics
细胞遗传学
基本信息
- 批准号:7944991
- 负责人:
- 金额:$ 9.99万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-04-17 至 2014-02-28
- 项目状态:已结题
- 来源:
- 关键词:Animal ModelApplications GrantsCancer CenterCancer Center Support GrantCell Culture TechniquesCellsChromosome BreakageClinicalClonalityColorComprehensive Cancer CenterCultured CellsCustomCytogenetic AnalysisCytogeneticsCytogenetics Shared ResourceData AnalysesDevelopmentDiagnosticDiseaseEmbryoFibroblastsFluorescent in Situ HybridizationFreezingGenesGeneticGrantHereditary DiseaseHome environmentHumanHybrid CellsImageInterphaseLaboratoriesLocationMalignant NeoplasmsMapsMayo Clinic Cancer CenterMetaphaseMicroscopeMolecular CytogeneticsMonitorMusParaffin EmbeddingPatternProcessProductionPrognostic MarkerPublicationsResearchResearch PersonnelResource SharingSamplingScientistServicesSlideSpecimenSpectral KaryotypingSystemTechniquesTissue MicroarrayTissuesTransgenesTumor Cell LineVisual AidXenograft procedurecell typeestablished cell linefluorescence microscopemeetingsmembernerve stem cellnovelprogramsresearch studytumor
项目摘要
The central focus of the Cytogenetics Shared Resource (CSR) is to provide cytogenetic and molecular
cytogenetic analysis of human and animal model research samples. These samples may be in the form of
cultured cells, fresh or frozen tissue, paraffin-embedded sections, or tissue microarrays (TMAs). Specific cell
types include tumor cell lines, xenograft cells, hybrid cells from chimeric animal models, neural stem cells,
and mouse embryonic fibroblasts, among others. The CSR provides specialized services including cell
culture, routine cytogenetic analysis, chromosome breakage analysis, interphase and metaphase
Fluorescence in situ Hybridization (FISH), Spectral Karyotyping (SKY) analysis of human and mouse
metaphases, and homebrew FISH Probe Production. This last service provides novel FISH probes that are
specific to investigators needs and are usually not commercially available. These probes are then used for
FISH analysis studies. The CSR is expanding this service beyond homebrew enumeration FISH probes by
creating custom translocation/fusion probes, break-apart probes, and multi-color FISH probes to ultimately
assist in developing strategic probes that become clinical diagnostic and prognostic markers of disease.
Other services provided by the CSR to meet the needs of investigators include utilization of the CSR
laboratory for slide processing and fluorescent microscope and imaging system use. Briefly, applications of
CSR services include: to characterize the clonality of tumor specimens; to determine the origin of a specific
tumor culture (i.e., mouse vs. human), to aid in the identification of genetic regions important for the
development of specific malignancies, and to map the location of DMA sequences, genes, or transgene
insertions. With the recognition that cancer is a genetic disease, many cancer researchers, including
scientists in the Mayo Clinic Cancer Center (MCCC), require access to CSR services. This Shared Resource
is utilized by 9 of the 12 Cancer Center Programs. Approximately 66% of CSR users are CCSG members
and represent 92% of the overall utilization.
细胞遗传学共享资源(CSR)的中心焦点是提供细胞遗传学和分子遗传学
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ROBERT B. JENKINS其他文献
ROBERT B. JENKINS的其他文献
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{{ truncateString('ROBERT B. JENKINS', 18)}}的其他基金
UNDERSTANDING THE INTERACTIONS BETWEEN GERMLINE AND SOMATIC ALTERATIONS in the PATHOGENESIS OF GLIOMAS
了解胶质瘤发病机制中种系和体细胞改变之间的相互作用
- 批准号:
10625788 - 财政年份:2018
- 资助金额:
$ 9.99万 - 项目类别:
(PQ3) UNDERSTANDING THE INTERACTIONS BETWEEN GERMLINE AND SOMATIC ALTERATIONS in the PATHOGENESIS OF GLIOMAS
(PQ3) 了解胶质瘤发病机制中种系和体细胞改变之间的相互作用
- 批准号:
10475617 - 财政年份:2018
- 资助金额:
$ 9.99万 - 项目类别:
Identification of 9p and 20q Germline Alterations in Glioblastoma Pathogenesis
胶质母细胞瘤发病机制中 9p 和 20q 种系改变的鉴定
- 批准号:
7814535 - 财政年份:2009
- 资助金额:
$ 9.99万 - 项目类别:
Identification of 9p and 20q Germline Alterations in Glioblastoma Pathogenesis
胶质母细胞瘤发病机制中 9p 和 20q 种系改变的鉴定
- 批准号:
7937827 - 财政年份:2009
- 资助金额:
$ 9.99万 - 项目类别:
Molecular Markers of Glioma Initiation and Progression
神经胶质瘤发生和进展的分子标志物
- 批准号:
6756565 - 财政年份:2001
- 资助金额:
$ 9.99万 - 项目类别:
Molecular Markers of Glioma Initiation and Progression
神经胶质瘤发生和进展的分子标志物
- 批准号:
6496855 - 财政年份:2001
- 资助金额:
$ 9.99万 - 项目类别:
Molecular Markers of Glioma Initiation and Progression
神经胶质瘤发生和进展的分子标志物
- 批准号:
6607199 - 财政年份:2001
- 资助金额:
$ 9.99万 - 项目类别:
Molecular Markers of Glioma Initiation and Progression
神经胶质瘤发生和进展的分子标志物
- 批准号:
6926925 - 财政年份:2001
- 资助金额:
$ 9.99万 - 项目类别:














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