PREVENTION OF ACTIVE TUBERCULOSIS BY INFECTION WITH H PYLORI

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们假设H.幽门螺杆菌可能非特异性地增强宿主免疫应答，并帮助维持M.潜伏状态的肺结核我们建议用两个特定的目标来测试这个新的假设，这两个目标利用了正在进行的人类和非人类灵长类动物结核潜伏期的研究。如果成功的话，随后的提案将开发一种干预措施，该干预措施将操纵天然微生物群来模拟这种保护性免疫反应，首先在非人类灵长类动物中进行，然后在人类中进行1期临床试验。 本项目的具体目的是确定潜伏期和H. pylori感染的食蟹猴中。结核

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We hypothesize that H. pylori may non-specifically boost the host immune response and help maintain M. tuberculosis in a latent state. We propose to test this novel hypothesis with two specific aims that exploit ongoing studies of tuberculosis latency in humans and in non-human primates. If successful, a subsequent proposal will develop an intervention that will manipulate the natural microbiota to mimic this protective immune response, first in non-human primates and then in a Phase 1 clinical trial in humans. The specific aim of this project is to determine the relationship between latency and the prevalence of H. pylori among cynomolgus monkeys challenged with M. tuberculosis.