PREVENTION OF ACTIVE TUBERCULOSIS BY INFECTION WITH H PYLORI

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 我们推测，幽门螺杆菌可能非特异性地增强宿主的免疫反应，并帮助维持结核分枝杆菌的潜伏状态。我们建议用两个特定的目标来检验这一新的假设，这两个目标是利用正在进行的关于人类和非人类灵长类动物中结核病潜伏期的研究。如果成功，后续的提案将开发一种干预措施，操纵自然微生物区系来模拟这种保护性免疫反应，首先是在非人类灵长类动物中，然后是在人类的第一阶段临床试验中。该项目的具体目的是确定感染结核分枝杆菌的食蟹猴的潜伏期与幽门螺杆菌感染率之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We hypothesize that H. pylori may non-specifically boost the host immune response and help maintain M. tuberculosis in a latent state. We propose to test this novel hypothesis with two specific aims that exploit ongoing studies of tuberculosis latency in humans and in non-human primates. If successful, a subsequent proposal will develop an intervention that will manipulate the natural microbiota to mimic this protective immune response, first in non-human primates and then in a Phase 1 clinical trial in humans. The specific aim of this project is to determine the relationship between latency and the prevalence of H. pylori among cynomolgus monkeys challenged with M. tuberculosis.