PREVENTION OF ACTIVE TUBERCULOSIS BY INFECTION WITH H PYLORI

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 我们假设H.幽门螺杆菌可能非特异性地增强宿主免疫应答，并帮助维持M.潜伏状态的肺结核我们建议用两个特定的目标来测试这个新的假设，这两个目标利用了正在进行的人类和非人类灵长类动物结核潜伏期的研究。如果成功的话，随后的提案将开发一种干预措施，该干预措施将操纵天然微生物群来模拟这种保护性免疫反应，首先在非人类灵长类动物中进行，然后在人类中进行1期临床试验。 本项目的具体目的是确定潜伏期和H. pylori感染的食蟹猴中。结核

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We hypothesize that H. pylori may non-specifically boost the host immune response and help maintain M. tuberculosis in a latent state. We propose to test this novel hypothesis with two specific aims that exploit ongoing studies of tuberculosis latency in humans and in non-human primates. If successful, a subsequent proposal will develop an intervention that will manipulate the natural microbiota to mimic this protective immune response, first in non-human primates and then in a Phase 1 clinical trial in humans. The specific aim of this project is to determine the relationship between latency and the prevalence of H. pylori among cynomolgus monkeys challenged with M. tuberculosis.